Evidence map›Paper›PMID 31100260›Full record

ArticleCell chemical biology2019

BMPing Up Healing Capacity with FKBP12 Ligand.

Charles H Williams, Charles C Hong

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Charles H WilliamsDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Charles C HongDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: charles.hong@som.umaryland.edu.

Funding

Chemical Genetic Analysis of Vertebrate DevelopmentR01GM118557 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HONG, CHARLES C · 2016 to 2019
$2.0M
NIGMS NIH HHS R01 GM118557
6 · The paper itself

Abstract

While the wound healing property of the macrolide FK506 is well known, the underlying mechanism has been elusive. In this issue of Cell Chemical Biology, Peiffer et al. (2019) utilize FKBP12 ligand to demonstrate that wound healing effects of FK506 occur via activation of the BMP (bone morphogenic protein) signaling pathway.

Indexed as

TacrolimusTacrolimus Binding Protein 1ALigandsSignal TransductionWound HealingLigandsTacrolimusTacrolimus Binding Protein 1A

Identifiers

PMID31100260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.