ArticleGut1987
Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats.
Article in Gut, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 147 citations in OpenAlex.
- Epidermal growth factor promotes proliferation and improves restoration after intestinal ischemia-reperfusion injury in rats.Inflammation · 2013Article
- To best measure cell proliferation in samples from the intestine.Cell proliferation · 2007Review
- Novel agents in the treatment of intestinal failure: humoral factors.Gastroenterology · 2006Review
- Leptin, cell proliferation and crypt fission in the gastrointestinal tract of intravenously fed rats.Cell proliferation · 2005Article
- Article
- Proglucagon-derived peptides in intestinal epithelial proliferation: glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats.Digestive diseases and sciences · 2001Article
- Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation.The American journal of pathology · 2000Article
- Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer.International journal of experimental pathology · 2000Article
- The effects of glutamine on intestinal epithelial cell proliferation in parenterally fed rats.Gut · 1999Article
- Cell proliferation in gastrointestinal mucosa.Journal of clinical pathology · 1999Review
- Aspects of the biology of regeneration and repair in the human gastrointestinal tract.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently.The American journal of pathology · 1997Article
- Article
- Development and validation of two solid-phase enzyme immunoassays (ELISA) for quantitation of human epidermal growth factors (hEGFs).Pharmaceutical research · 1996Article
- Article
- Article
- Mesenchymal-epithelial interactions in the bladder.World journal of urology · 1996Review
- Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat.Urological research · 1996Article
- Role of epidermal growth factor in peptic ulcer healing.Digestive diseases and sciences · 1995Review
- Growth factor regulation of proliferation in primary cultures of small intestinal epithelium.In vitro cellular & developmental biology. Animal · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of beta-urogastrone/human epidermal growth factor (URO-EGF) on intestinal epithelial cell proliferation were studied in rats in which intestinal cell proliferation had been reduced to a steady state basal level, by maintaining the rats on total parenteral nutrition. The accumulation of arrested metaphases over a two hour time period was determined in a dose response study. Increasing doses of URO-EGF progressively raised the two hour collection of metaphases and intestinal weights. Intravenous infusion of URO-EGF was also effective in restoring cell proliferation when it was infused after the intestine had become hypoproliferative. beta-urogastrone/human epidermal growth factor administered through an intragastric cannulae thrice daily had no significant effect on intestinal weight or crypt cell production rate or metaphase collection. It is proposed that one of the in vivo actions of urogastrone-epidermal growth factor is the maintenance of gastrointestinal growth and that this occurs through a systemic rather than a luminal mechanism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.