Observational studyPloS one2019
Antimicrobial use-related problems and their costs in surgery ward of Jimma University Medical Center: Prospective observational study.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Inappropriate antibiotic prescribing in Ethiopian hospitals: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Medication-related problems and adverse drug reactions in Ethiopia: A systematic review.Pharmacology research & perspectives · 2020Pooled it
- Antimicrobial use, prescribing quality, and therapy-related problems among hospitalized patients in Northeast Ethiopia.Scientific reports · 2025Article
- Observational
- Surgical Antibiotic Prophylaxis Used in A University Clinics Hospital and Antibiotic Costs: A 3-year Survey.Current therapeutic research, clinical and experimental · 2025Article
- Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study.Infection and drug resistance · 2024Article
- Article
- Cefazolin access and use in Ethiopia: A policy implication.PLOS global public health · 2023Article
- Opportunities, associations, and impact of early intravenous to oral antimicrobial switch for hospitalized patients in Ethiopia.SAGE open medicine · 2023Article
- Antimicrobial use related problems and determinants in surgical ward of Ethiopian tertiary hospital.PloS one · 2023Observational
- Etiquette of the antibiotic decision-making process for surgical prophylaxis in Ethiopia: a triangulated ethnographic study.Frontiers in public health · 2023Observational
- Antibiotics use evaluation among hospitalized adult patients at Jimma Medical Center, southwestern Ethiopia: the way to pave for antimicrobial stewardship.Journal of pharmaceutical policy and practice · 2022Article
- Antimicrobial use-related drug therapy problems and associated factors among patients in the medical ward of Wachemo University Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Southwest Ethiopia.SAGE open medicine · 2022Article
- Appropriate Use of Ceftriaxone in Sub-Saharan Africa: A Systematic Review.Infection and drug resistance · 2021Review
- Predictors of prolonged length of hospital stay and in-hospital mortality among adult patients admitted at the surgical ward of Jimma University medical center, Ethiopia: prospective observational study.Journal of pharmaceutical policy and practice · 2020Article
- Drug Therapy Problems and the Role of Clinical Pharmacist in Surgery Ward: Prospective Observational and Interventional Study.Drug, healthcare and patient safety · 2020Article
- The Association Between Incorrect Use of Antibiotic Prophylaxis and in-Hospital Surgical Site Infections - A Prospective Observational Study.Infection and drug resistance · 2020Article
- Antimicrobial Drug Therapy Problems Among Patients in the Outpatient Department of Ataye Hospital, Northeast Ethiopia.Infection and drug resistance · 2020Article
- Surgical Site Infections and Prophylaxis Antibiotic Use in the Surgical Ward of Public Hospital in Western Ethiopia: A Hospital-Based Retrospective Cross-Sectional Study.Infection and drug resistance · 2020Article
- Drug Therapy Problems and Predictors Among Patients Admitted to Medical Wards of Dilla University Referral Hospital, South Ethiopia: A Case of Antimicrobials.Infection and drug resistance · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAntibiotics are among the most commonly misused of all drugs, which results in antibiotic resistance and waste of resources and it has not been studied in Ethiopia. Therefore, this study was carried out to assess antibiotic use-related problems and their costs among patients hospitalized at the surgical ward of Jimma University Medical Center.
methodsHospital-based prospective observational study was used to assess the prevalence, cost, and determinants of antibiotic use-related problems; multiple stepwise backward logistic regression analysis was done for a P value of < 0.25 to look for predictors of antibiotic use-related problems. Written informed consent was obtained and confidentiality was secured.
resultsAmong 300 participants, antibiotic use-related problems (ABURPs) were found in 69.3% of the study participants. The direct total cost attributed to these problems was approximated to a minimum of 2230.15 US$. Independent predictors for antibiotic use-related problems were: indication for antibiotic use like: use of antibiotic for prophylaxis; p < 0.0001, antibiotic use for both therapeutic & prophylaxis; p < 0.0001, CDC wound class I and II; p = 0.016 and; p = 0.002 respectively, overall poly-pharmacy and greater than 2 antibiotic exposure during hospital stay; p = 0.019and p = 0.006 respectively and hospital stay for ≥21 days; p = 0.007.
conclusionThe prevalence of antibiotic use-related problems was high and resulted in extra cost. Antibiotic use for prophylaxis, prophylaxis, and treatment, poly-pharmacy, greater than 2 antibiotic exposures during the hospital stay, CDC wound class I and II, and duration of hospital stay of ≥ 21 days was found to be independent predictors of antibiotic use-related problems.
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