ArticleEuropean journal of immunology2019
Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs.
Article in European journal of immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Extracellular Vesicles From Schistosoma mansoni Adult Worms Stimulate IL-10 Release by B Cells.Parasite immunology · 2025Article
- Review
- Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.Nature communications · 2023Article
- Circulating B10 regulatory cells are decreased in severe and critical COVID-19.Journal of leukocyte biology · 2022Article
- Schistosome immunomodulators.PLoS pathogens · 2021Review
- Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughoutImmunoHorizons · 2021Article
- B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments.Oncogene · 2021Review
- Use of Toll-Like Receptor (TLR) Ligation to Characterize Human Regulatory B-Cells Subsets.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Potential Role of Schistosome-Associated Factors as Therapeutic Modulators of the Immune System.Infection and immunity · 2020Review
- Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease.Frontiers in immunology · 2020Review
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The helminth Schistosoma mansoni (S. mansoni) induces a network of regulatory immune cells, including interleukin (IL)-10-producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized. Recent reports suggest that helminths induce type I interferons (IFN-I), and that IFN-I drive the development of Bregs in humans. We therefore assessed the role of IFN-I in the induction of Bregs by S. mansoni. Mice chronically infected with S. mansoni or i.v. injected with S. mansoni soluble egg antigen (SEA) developed a systemic IFN-I signature. Recombinant IFN-α enhanced IL-10 production by Bregs stimulated with S. mansoni SEA in vitro, while not activating Bregs by itself. IFN-I signaling also supported ex vivo IL-10 production by SEA-primed Bregs but was dispensable for activation of S. mansoni egg-induced Bregs in vivo. These data indicate that although IFN-I can serve as a coactivator for Breg IL-10 production, they are unlikely to participate in the development of Bregs in response to S. mansoni eggs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.