ArticleBrain : a journal of neurology2019
Characterizing the role of the structural connectome in seizure dynamics.
Article in Brain : a journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- White matter signals reflect information transmission between brain regions during seizures.Brain : a journal of neurology · 2026Article
- Emergent multiscale organisation of neural dynamics fragments in anaesthesia.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Structural and dynamic functional controllability: shared variance between network control metrics limits attribution to distinct domains of intelligence.Frontiers in human neuroscience · 2026Article
- Harnessing electroencephalography connectomes for cognitive and clinical neuroscience.Nature biomedical engineering · 2025Review
- Groupwise registration of infant brain diffusion tensor images using intermediate subgroup templates.PloS one · 2025Article
- Seizure network characterization by functional connectivity mapping and manipulation.Neurophotonics · 2025Article
- Explaining slow seizure propagation with white matter tractography.Brain : a journal of neurology · 2024Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- EEG Ictal Power Dynamics, Function-Structure Associations, and Epilepsy Surgical Outcomes.Neurology · 2024Article
- iEEG-recon: A fast and scalable pipeline for accurate reconstruction of intracranial electrodes and implantable devices.Epilepsia · 2024Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Therapeutic approaches targeting seizure networks.Frontiers in network physiology · 2024Review
- Network coupling and surgical treatment response in temporal lobe epilepsy: A proof-of-concept study.Epilepsy & behavior : E&B · 2023Article
- Article
- Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery.Neurology · 2023Article
- SEEG-based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure.Epilepsia open · 2023Article
- The Interictal Suppression Hypothesis in focal epilepsy: network-level supporting evidence.Brain : a journal of neurology · 2023Article
- Deep learning distinguishes connectomes from focal epilepsy patients and controls: feasibility and clinical implications.Brain communications · 2023Article
- Chronic intracranial EEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states.Brain communications · 2023Article
- Interictal Functional Connectivity in Focal Refractory Epilepsies Investigated by Intracranial EEG.Brain connectivity · 2022Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
How does the human brain's structural scaffold give rise to its intricate functional dynamics? This is a central question in translational neuroscience that is particularly relevant to epilepsy, a disorder affecting over 50 million subjects worldwide. Treatment for medication-resistant focal epilepsy is often structural-through surgery or laser ablation-but structural targets, particularly in patients without clear lesions, are largely based on functional mapping via intracranial EEG. Unfortunately, the relationship between structural and functional connectivity in the seizing brain is poorly understood. In this study, we quantify structure-function coupling, specifically between white matter connections and intracranial EEG, across pre-ictal and ictal periods in 45 seizures from nine patients with unilateral drug-resistant focal epilepsy. We use high angular resolution diffusion imaging (HARDI) tractography to construct structural connectivity networks and correlate these networks with time-varying broadband and frequency-specific functional networks derived from coregistered intracranial EEG. Across all frequency bands, we find significant increases in structure-function coupling from pre-ictal to ictal periods. We demonstrate that short-range structural connections are primarily responsible for this increase in coupling. Finally, we find that spatiotemporal patterns of structure-function coupling are highly stereotyped for each patient. These results suggest that seizures harness the underlying structural connectome as they propagate. Mapping the relationship between structural and functional connectivity in epilepsy may inform new therapies to halt seizure spread, and pave the way for targeted patient-specific interventions.
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