Evidence map›Paper›PMID 31099706›Full record

ArticleHuman vaccines & immunotherapeutics2019

Is hepatitis B antigen in cord blood an immunotolerogen playing a critical role in the pathogenesis of chronic hepatitis B?

Hongyu Huang, Mingzhe Ning, Jingli Liu, Jie Chen, Jing Feng, Yimin Dai, Yali Hu, Yi-Hua Zhou

Open access · bronzeAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hongyu HuangDepartment of Laboratory Medicine and Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.
Mingzhe NingDepartment of Laboratory Medicine and Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.
Jingli LiuDepartment of Laboratory Medicine and Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.
Jie ChenDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.
Jing FengDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.
Yimin DaiDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.ORCID 0000-0002-5266-1797
Yali HuDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.
Yi-Hua ZhouDepartment of Laboratory Medicine and Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School , Jiangsu , China.ORCID 0000-0001-8880-0392
Nanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we showed that infants with or without fetal hepatitis B e antigen (HBeAg) exposure had comparable antibody response to hepatitis B vaccination and proposed that fetal HBeAg exposure appears to not induce immunotolerance to HBV. Here, we summarized the different results on the topic of fetal HBeAg exposure in inducing immunotolerance to HBV nucleocapsid protein, and the evidence to back up that the tendency of high infection rate in infants of HBeAg-positive mothers is more likely associated with higher maternal viral loads and is less likely associated with the fetal HBeAg exposure. We consider that whether fetal HBeAg exposure plays an important role in the pathogenesis of chronic HBV infection remains to be an open question.

Indexed as

Hepatitis B, ChronicHepatitis B e AntigensFemaleFetal BloodHepatitis B Surface AntigensHepatitis B virusHumansInfantInfectious Disease Transmission, VerticalHepatitis B e AntigensHepatitis B Surface Antigenschronic HBV infectionfetal exposureHBeAg

Identifiers

PMID31099706
PMCPMC6773396
OpenAlexW2946437345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.