ArticleOrganic letters2019
Regio- and Enantioselective Synthesis of 1,2-Diamine Derivatives by Copper-Catalyzed Hydroamination.
Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Iridium-catalysed hydroamination of internal homoallylic amines.Chemical communications (Cambridge, England) · 2024Article
- Electrophilic Aminating Agents in Total Synthesis.Angewandte Chemie (International ed. in English) · 2021Review
- CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition.Accounts of chemical research · 2020Article
- Distinctive reactivity ofBeilstein journal of organic chemistry · 2020Article
- Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination.Organic letters · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A highly regio- and enantioselective synthesis of 1,2-diamine derivatives from γ-substituted allylic pivalamides using copper-catalyzed hydroamination is reported. The N-pivaloyl group is essential, in both facilitating the hydrocupration step and suppressing an unproductive β-elimination from the alkylcopper intermediate. This approach enables an efficient construction of chiral differentially protected vicinal diamines under mild conditions with broad functional group tolerance.
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