Observational studyJournal of thrombosis and haemostasis : JTH2019
Association of complete blood count parameters, d-dimer, and soluble P-selectin with risk of arterial thromboembolism in patients with cancer.
Observational study in Journal of thrombosis and haemostasis : JTH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Systematic review of observational studies reporting antiphospholipid antibodies in patients with solid tumors.Blood advances · 2020Pooled it
- Cancer and arterial thrombosis: therapeutic options.Research and practice in thrombosis and haemostasis · 2024Article
- Arterial Thrombosis in Patients with Acute Myeloid Leukemia: Incidence and Risk Factors.Cancers · 2023Article
- A nomogram model to predict the portal vein thrombosis risk after surgery in patients with pancreatic cancer.Frontiers in surgery · 2023Article
- Soluble P-selectin level in patients with cancer-associated venous and artery thromboembolism: a systematic review and meta-analysis.Archives of medical science : AMS · 2023Article
- The effects of exercise and active assisted cycle ergometry in post-operative total knee arthroplasty patients - a randomized controlled trial.Journal of experimental orthopaedics · 2021Article
- Cancer and Clot: A Deadly Dance.JACC. CardioOncology · 2021Article
- Increased Incidence of Venous Thromboembolism with Cancer Immunotherapy.Med (New York, N.Y.) · 2021Article
- Article
- Mechanisms and biomarkers of cancer-associated thrombosis.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Expression of TRA2B in endometrial carcinoma and its regulatory roles in endometrial carcinoma cells.Oncology letters · 2019Article
- Association of complete blood count parameters, d-dimer, and soluble P-selectin with risk of arterial thromboembolism in patients with cancer.Journal of thrombosis and haemostasis : JTH · 2019Observational
- Relationship of Platelet Glycoprotein IIb/IIIa and CD62P With Hypercoagulable State After Oncologic Surgery.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
- Isolated distal deep vein thrombosis: Diagnosis and management.Science progressReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPatients with cancer are at risk of developing arterial thromboembolism (ATE). With the prevalence of cancer and cardiovascular diseases on the rise, the identification of risk factors for ATE in patients with cancer is of emerging importance.
objectivesAs data on the association of potential biomarkers with risk of ATE in patients with cancer are scarce, we conducted a cohort study with the aim to identify blood-based biomarkers for ATE risk prediction in patients with cancer. PATIENTS/
methodsOverall, 1883 patients with newly diagnosed cancer or progressive disease after complete or partial remission were included and followed for 2 years. Venous blood was drawn at study inclusion for measurement of complete blood count parameters, total cholesterol, d-dimer, and soluble P-selectin (sP-selectin) levels.
resultsThe 2-year cumulative incidence of ATE was 2.5%. In univariable analysis, red cell distribution width (subdistribution hazard ratio (SHR) per doubling: 4.4, 95% CI: 1.4-14.1), leukocyte count (1.2, 1.1-1.5), neutrophil count (1.6, 1.1-2.3), and sP-selectin levels (1.9, 1.3-2.7) were associated with risk of ATE in patients with cancer; d-dimer was not associated with the risk of ATE (1.1, 0.9-1.4). After adjustment for age, sex, and smoking status the association prevailed for the neutrophil count (adjusted [adj.] SHR per doubling: 1.6, 1.1-2.4), and sP-selectin levels (1.8, 1.2-2.8).
conclusionsAn elevated absolute neutrophil count and higher sP-selectin levels were associated with an increased risk of ATE in patients with cancer. Their role for predicting cancer-related ATE needs to be validated in further studies.
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