Evidence map›Paper›PMID 31099415›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2019

Multidisciplinarity in Microbiome Research: A Challenge and Opportunity to Rethink Causation, Variability, and Scale.

Katherine R Amato, Corinne F Maurice, Karen Guillemin, Tamara Giles-Vernick

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine R AmatoHumans and the Microbiome Program, Canadian Institute for Advanced Research, 661 University Avenue, Suite 505, Toronto, ON, M5G 1Z8, Canada.
Corinne F MauriceHumans and the Microbiome Program, Canadian Institute for Advanced Research, 661 University Avenue, Suite 505, Toronto, ON, M5G 1Z8, Canada.
Karen GuilleminHumans and the Microbiome Program, Canadian Institute for Advanced Research, 661 University Avenue, Suite 505, Toronto, ON, M5G 1Z8, Canada.
Tamara Giles-VernickHumans and the Microbiome Program, Canadian Institute for Advanced Research, 661 University Avenue, Suite 505, Toronto, ON, M5G 1Z8, Canada.ORCID 0000-0003-2873-8544

Funding

Research Area IIIP50GM098911 · NIGMS · UNIVERSITY OF OREGON · PI PARTHASARATHY, RAGHUVEER · 2012 to 2016
$9.8M
Live Imaging CoreP01GM125576 · NIGMS · UNIVERSITY OF OREGON · PI GUILLEMIN, KAREN J · 2018 to 2022
$7.8M
NIGMS NIH HHS P01 GM125576NIGMS NIH HHS P50 GM098911
6 · The paper itself

Abstract

This essay, written by a biologist, a microbial ecologist, a biological anthropologist, and an anthropologist-historian, examines tensions and translations in microbiome research on animals in the laboratory and field. The authors trace how research questions and findings in the laboratory are extrapolated into the field and vice versa, and the shifting evidentiary standards that these research settings require. Showing how complexities of microbiomes challenge traditional standards of causation, the authors contend that these challenges require new approaches to inferences used in ecology, anthropology, and history. As social scientists incorporate investigations of microbial life into their human studies, microbiome researchers venture into field settings to develop mechanistic understandings about the functions of complex microbial communities. These efforts generate new possibilities for cross-fertilizations and inference frameworks to interpret microbiome findings. Microbiome research should integrate multiple scales, levels of variability, and other disciplinary approaches to tackle questions spanning conditions from the laboratory to the field.

Indexed as

Interdisciplinary ResearchAnimalsEcologyHost Microbial InteractionsHumansMicrobiotaModels, Animalanimal modelscausationecologyfield investigationlaboratory investigationmicrobiomesocial sciences

Identifiers

PMID31099415
PMCPMC6756940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.