ArticleMolecular biology and evolution2019
Response to Comment on "microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes".
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Distinct roles of clustered MicroRNAs miR-286 and miR-6 in JNK activation critical to apoptosis-induced proliferation in Drosophila.Cellular and molecular life sciences : CMLS · 2025Article
- Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells.Biophysical reviews · 2021Article
Corrections and comments
- Comment on
- Comment on
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metazoan miRNAs are significantly enriched in clusters. In a previous study (Wang, et al. 2016), we proposed a "functional co-adaptation" model to explain how clustering helps new miRNAs survive and develop functions during long-term evolution. Recently, Marco re-analyzed our data and came to a different conclusion. The major concern Marco raised is whether the observed number of genes targeted by at least two conserved miRNAs with different seeds from the same miRNA clusters is statistically higher than the number obtained under the assumption of randomness. Marco claimed that our approach of shuffling miRNA-target interactions would lead to spuriously low P values. Marco also argued our observation that clustered miRNAs have more common targets than expected is mostly contributed by seeds with similar sequences. However, we found his analyses were conducted in an inappropriate approach and do not refute our model. We also provide new evidences to reaffirm our model.
Indexed as
Identifiers
31099389What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.