Evidence map›Paper›PMID 31099350›Full record

ReviewBiomaterials science2019

Biomaterials in fetal surgery.

Sally M Winkler, Michael R Harrison, Phillip B Messersmith

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sally M WinklerDepartment of Bioengineering, University of California, Berkeley, CA, USA. philm@berkeley.edu and University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-2137-2383
Michael R HarrisonDivision of Pediatric Surgery, UCSF Benioff Children's Hospital, San Francisco, CA, USA.
Phillip B MessersmithDepartment of Bioengineering, University of California, Berkeley, CA, USA. philm@berkeley.edu and Department of Materials Science and Engineering, University of California, Berkeley, CA, USA and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-1197-333X

Funding

Bioinspired Polymers for Fetal Membrane Pre-SealingR01EB022031 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI MESSERSMITH, PHILLIP B · 2016 to 2019
$1.3M
NIBIB NIH HHS R01 EB022031
6 · The paper itself

Abstract

Fetal surgery and fetal therapy involve surgical interventions on the fetus in utero to correct or ameliorate congenital abnormalities and give a developing fetus the best chance at a healthy life. Historical use of biomaterials in fetal surgery has been limited, and most biomaterials used in fetal surgeries today were originally developed for adult or pediatric patients. However, as the field of fetal surgery moves from open surgeries to minimally invasive procedures, many opportunities exist for innovative biomaterials engineers to create materials designed specifically for the unique challenges and opportunities of maternal-fetal surgery. Here, we review biomaterials currently used in clinical fetal surgery as well as promising biomaterials in development for eventual clinical translation. We also highlight unmet challenges in fetal surgery that could particularly benefit from novel biomaterials, including fetal membrane sealing and minimally invasive myelomeningocele defect repair. Finally, we conclude with a discussion of the underdeveloped fetal immune system and opportunities for exploitation with novel immunomodulating biomaterials.

Indexed as

Biocompatible MaterialsFetal TherapiesFetusHumansImmunityRiskBiocompatible Materials

Identifiers

PMID31099350
PMCPMC8232972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.