Evidence map›Paper›PMID 31099252›Full record

Trial reportAIDS research and human retroviruses2019

Antiretroviral Activity of AMD11070 (An Orally Administered CXCR4 Entry Inhibitor): Results of NIH/NIAID AIDS Clinical Trials Group Protocol A5210.

Victoria A Johnson, Yoninah S Cramer, Susan L Rosenkranz, Stephen Becker, Karin L Klingman, Beatrice Kallungal, Eoin Coakley, Edward P Acosta, Gary Calandra, Michael S Saag and 1 more

Open access · greenAbstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph

Trial report in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Victoria A Johnson1Birmingham Veterans Affairs Medical Center, Birmingham, Alabama.
Yoninah S Cramer3Statistical and Data Management Center, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Susan L Rosenkranz3Statistical and Data Management Center, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Stephen Becker4AnorMED, Inc., Langley, British Columbia, Canada.
Karin L Klingman5Division of AIDS, NIAID/NIH, Bethesda, Maryland.
Beatrice Kallungal6Social and Scientific Systems, Inc., Silver Spring, Maryland.
Eoin Coakley7Monogram Biosciences, Inc., South San Francisco, California.
Edward P Acosta2Department of Pharmacology and Toxicology, The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
Gary Calandra4AnorMED, Inc., Langley, British Columbia, Canada.
Michael S Saag2Department of Pharmacology and Toxicology, The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
NIH/NIAID AIDS Clinical Trials Group A5210 Protocol Team
Cancer Research And Biostatistics · USUniversity of Alabama at Birmingham · USBirmingham VA Medical Center · USOffice of AIDS Research · USSocial and Scientific Systems (United States) · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
WOMEN'S HEALTH AGENDAU01AI038858 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI BENSON, CONSTANCE ANN · 1996 to 2008
$157.5M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Statistical and Data Management Center for the AIDS Clinical Trials GroupU01AI068634 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUGHES, MICHAEL DAVID · 2006 to 2010
$71.9M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
A-Z Clinical Trials UnitUM1AI069452 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 2012 to 2026
$28.8M
Northwestern University Clinical Trial UnitUM1AI069471 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Chad J Achenbach · 2012 to 2026
$24.6M
Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
Alabama-Clinical Trials UnitU01AI069452 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, MICHAEL S. · 2007 to 2011
$16.6M
NCRR NIH HHS M01 RR000032NCRR NIH HHS UL1 RR025008NCRR NIH HHS UL1 RR025761NIAID NIH HHS P30 AI027767NIAID NIH HHS T32 AI007493NIAID NIH HHS U01 AI025859NIAID NIH HHS U01 AI038858NIAID NIH HHS U01 AI068634NIAID NIH HHS U01 AI068636NIAID NIH HHS U01 AI069418NIAID NIH HHS U01 AI069452NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069452NIAID NIH HHS UM1 AI069471NIMH NIH HHS R01 MH050421
6 · The paper itself

Abstract

AMD11070 binds to the chemokine receptor CXCR4, with anti-HIV-1 activity

Indexed as

AdultAminoquinolinesAnti-HIV AgentsBenzimidazolesButylaminesCD4-Positive T-LymphocytesFemaleHeterocyclic Compounds, 1-RingHIV-1HumansMaleProof of Concept StudyReceptors, CXCR4RNA, ViralUnited StatesVirus InternalizationAminoquinolinesAnti-HIV AgentsBenzimidazolesButylaminesCXCR4 protein, humanHeterocyclic Compounds, 1-RingmavorixaforReceptors, CXCR4RNA, ViralAMD11070CXCR4 inhibitorHIV-1 entry inhibitors

Identifiers

PMID31099252
PMCPMC6688111
OpenAlexW2945547518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.