ArticleAmerican journal of dentistry2018
Synthesis, antibacterial activity, and biocompatibility of new antibacterial dental monomers.
Article in American journal of dentistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Quaternary Ammonium Dimethacrylates as an Additive in Dental Composite Resins: A Review of Their Antimicrobial, Mechanical, and Physicochemical Properties.Materials (Basel, Switzerland) · 2025Review
- Structure-properties correlation of acrylic resins modified with silver vanadate and graphene.Heliyon · 2024Review
- Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds.International journal of molecular sciences · 2024Review
- Formulation and characterization of experimental orthodontic adhesive containing antibacterial dimethacrylate DABCO monomers: An in vitro study.International orthodontics · 2022Article
- Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to InhibitJournal of functional biomaterials · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo synthesize a small library of antibacterial dental monomers based on quaternary ammonium salts and to test their antibacterial activity against cariogenic bacteria.
methodsFive new antibacterial monomers were synthesized and characterized by NMR, IR and HRMS.
resultsCytotoxicity assays using human gingival fibroblast cells showed that these new antibacterial monomers were biocompatible at concentrations of 10⁻⁵ M and displayed less cytotoxicity than BisGMA, a common dental monomer. When analyzed in vitro, all new monomers demonstrated strong inhibitory activity against biofilm formation by cariogenic Streptococcus mutans and Lactobacillus casei. Results indicated that antibacterial monomers containing a long alkyl (i.e. hexadecyl) chain are superior to their shorter-chain counterparts. The cross-linking monomers based on glycerol dimethacrylate also consistently outperformed their monomethacrylate analogs. Finally, the ammonium salts containing the dimethylbenzyl moiety were superior to the similar structures containing 1,4-diazabicyclo[2.2.2]octane (DABCO) in some cases. CLINICAL SIGNIFICANCE: All five new monomers were deemed biocompatible at concentrations of 10⁻⁵ M or less, and most had better biocompatibility than BisGMA. Dimethacrylate monomers 5 and 6 generally demonstrated high antibacterial activities, with the highest activity shown for the most lipophilic monomer 6, and these new antibacterial monomers have potential future application in dental composites and bonding agents.
Indexed as
Identifiers
31099208PMC7161594What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.