ArticleGenes, brain, and behavior2019
Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Genes, brain, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
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- Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.Development and psychopathology · 2023Article
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
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- Genetic Addiction Risk and Psychological Profiling Analyses for "Preaddiction" Severity Index.Journal of personalized medicine · 2022Article
- Understanding Anhedonia from a Genomic Perspective.Current topics in behavioral neurosciences · 2022Review
- Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study.Molecular psychiatry · 2021Article
- Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.Exploration of medicine · 2021Article
- Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay.Alcoholism, clinical and experimental research · 2020Article
- Associations between the development of PTSD symptoms and longitudinal changes in the DNA methylome of deployed military servicemen: A comparison with polygenic risk scores.Comprehensive psychoneuroendocrinology · 2020Article
- Recent advances in genetic studies of alcohol use disorders.Current genetic medicine reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
24 authors at 11 institutions in 1 country.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.ORCID 0000-0001-7803-580X
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Washington University, Saint Louis, Missouri.ORCID 0000-0003-0394-777X
Andrey AnokhinDepartment of Psychiatry, Washington University School of Medicine, Washington University, Saint Louis, Missouri.
Lance BauerDepartment of Psychiatry, University of Connecticut School of Medicine, University of Connecticut, Farmington, Connecticut.
Kathleen K BucholzDepartment of Psychiatry, Washington University School of Medicine, Washington University, Saint Louis, Missouri.
Danielle M DickDepartment of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0002-1636-893X
Ahmad R HaririDepartment of Psychology, Duke Institute for Brain Sciences, Duke University, Durham, North Carolina.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, University of Connecticut, Farmington, Connecticut.
Chella KamarajanSUNY. Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York.
John KramerDepartment of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Samuel KupermanDepartment of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Jacquelyn L MeyersSUNY. Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York.
John I NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.
Marc SchuckitDepartment of Psychiatry, University of California San Diego, San Diego, California.
Denise M ScottDepartments of Pediatrics and Human Genetics, Howard University, Washington, District of Columbia.
Robert E TaylorDepartment of Pharmacology, Howard University, Washington, District of Columbia.
Jay TischfieldDepartment of Genetics, Rutgers University, Piscataway, New Jersey.
Bernice PorjeszSUNY. Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York.
Alison M GoateDepartment of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, New York.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.
Ryan BogdanDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, Saint Louis, Missouri.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Washington University, Saint Louis, Missouri.
Indiana University School of MedicineWashington University in St. Louis · USSUNY Downstate Health Sciences University · USHoward University · USUniversity of Connecticut · USUniversity of Iowa · USDuke University · USIcahn School of Medicine at Mount Sinai · USRutgers, The State University of New Jersey · USUniversity of California San Diego · USVirginia Commonwealth University · US
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MMAPPING THE HUMAN CONNECTOME DURING TYPICAL AGINGU01AG052564 · NIA · WASHINGTON UNIVERSITY · PI SALAT, DAVID H, TERPSTRA, MELISSA J · 2016 to 2020
$18.9MQuantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M7/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109532 · NIMH · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2016 to 2020
$3.1MGENETICS, THE ADOLESCENT BRAIN, AND ADDICTION LIABILITY: A LONGITUDINAL TWIN STUDYR01HD083614 · NICHD · WASHINGTON UNIVERSITY · PI ANOKHIN, ANDREY P. · 2016 to 2020
$3.0MNEUROCOGNITIVE CONSEQUENCES OF ADOLESCENT MARIJUANA USER01DA040716 · NIDA · WASHINGTON UNIVERSITY · PI ANOKHIN, ANDREY P. · 2017 to 2021
$3.0MPersonality and Health in Later Life: Psychosocial and Biological MechanismsR01AG045231 · NIA · WASHINGTON UNIVERSITY · PI OLTMANNS, THOMAS · 2014 to 2018
$2.9M3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MSelf-Regulation Failure: Identifying and Modifying a Risk PhenotypeR01DA031579 · NIDA · DUKE UNIVERSITY · PI HARIRI, AHMAD R., STRAUMAN, TIMOTHY J · 2010 to 2012
$1.9MNeurogenetic Pathways to Drug Use in Young AdultsR01DA033369 · NIDA · DUKE UNIVERSITY · PI HARIRI, AHMAD R. · 2013 to 2016
$1.4MNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02AA018755NIAAA NIH HHS U10 AA008401NIA NIH HHS R01 AG045231NIA NIH HHS R01 AG049789NIA NIH HHS U01 AG052564NIA NIH HHS U24 AG021886NICHD NIH HHS R01 HD083614NIDA NIH HHS DA033369NIDA NIH HHS K01 DA037914NIDA NIH HHS K01DA037914NIDA NIH HHS K02 DA032573NIDA NIH HHS K02DA32573NIDA NIH HHS R01 DA031579NIDA NIH HHS R01 DA033369NIDA NIH HHS R01 DA040411NIDA NIH HHS R01 DA040716NIDA NIH HHS R21 DA038834NIH HHS AG045231NIH HHS AG052564NIH HHS DA038834NIH HHS DA040716NIH HHS HD083614NIH HHS R01-AG049789NIH HHS R01-DA031579NIH HHS S10 OD018164NIH HHS S10 OD018522NIMH NIH HHS MH109532NIMH NIH HHS U01 MH109532NIMH NIH HHS U01 MH109536
Abstract
Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome-wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP) among 7291 European-Americans (EA; 2927 cases) and 3132 African-Americans (AA: 1315 cases) participating in the family-based Collaborative Study on the Genetics of Alcoholism. ANYDEP was heritable (h
Indexed as
Polymorphism, Single NucleotideBlack or African AmericanChromosomes, Human, Pair 13Chromosomes, Human, Pair 3Genetic LociHumansPhenotypeRewardSubstance-Related DisordersVentral StriatumWhite PeopleAfrican-Americanalcohol dependencedrug dependenceEuropean-AmericanfMRIgeneticsGWASheritabilityneural rewardventral striatum
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.