ArticleAddiction biology2020
Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity.
Article in Addiction biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats.Neuropharmacology · 2025Article
- Age is associated with altered locomotor and hypothermic response to acute nicotine.Behavioural pharmacology · 2025Article
- Association between smoking behavior and sleep health among South Korean adolescents: A cross-sectional study 2020-2023.Tobacco induced diseases · 2025Article
- Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety- and working memory impairment-related behavioural effects of nicotine as a stressor.Addiction biology · 2024Article
- Practical solutions for including sex as a biological variable (SABV) in preclinical neuropsychopharmacological research.Journal of neuroscience methods · 2024Review
- Individual Differences in Substance Use Motives, Trauma, and Stress Among College-Based Polysubstance Users.Substance use & misuse · 2024Article
- The impact of adolescent stress on nicotine use and affective disorders in rodent models.The European journal of neuroscience · 2022Review
- The effects of alcohol drinking on subsequent methamphetamine self-administration and relapse in adolescent female rats.Behavioural brain research · 2022Article
- The effects of stress on avoidance in rodents: An unresolved matter.Frontiers in behavioral neuroscience · 2022Review
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats.Psychopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Adolescence represents increased susceptibility to stress that increases risk for nicotine dependence. The present study examined the interactive effects of brief exposure to stress (shipping/transportation or experimentally induced) and chronic nicotine during adolescence on cognitive function and stress reactivity in adulthood. Adolescent (P31), but not young adult (P47), C57BL/6J mice had higher levels of corticosterone after shipping vs mice bred onsite. Shipped preadolescent (P23) and adolescent (P38) mice, but not those bred onsite, exposed to nicotine showed deficits in contextual fear learning when tested in adulthood. Adult learning deficits were replicated in adolescent mice bred onsite, exposed to experimentally induced stress, and administered chronic nicotine. Stress and nicotine during adolescence resulted in higher expression of hippocampal glucocorticoid receptors and corticotropin-releasing factor receptors and blunted restraint induced CORT release in adulthood. Importantly, studies examining adolescent behavior in mice should consider stress influences outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.