ArticleJournal of veterinary internal medicine2019
Investigation of blood biomarkers for the diagnosis of mild to moderate asthma in horses.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Biomarkers of equine asthma: A review of the current literature.Veterinary research communications · 2026Review
- Equine Asthma Diagnostics: Review of Influencing Factors and Difficulties in Diagnosing Subclinical Disease.Animals : an open access journal from MDPI · 2024Review
- Clinical variability of equine asthma phenotypes and analysis of diagnostic steps in phenotype differentiation.Acta veterinaria Scandinavica · 2024Article
- The Most Common Environmental Risk Factors for Equine Asthma-A Narrative Review.Animals : an open access journal from MDPI · 2024Review
- The Immune Mechanisms of Severe Equine Asthma-Current Understanding and What Is Missing.Animals : an open access journal from MDPI · 2022Review
- Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity.Frontiers in immunology · 2022Article
- Airway remodeling in horses with mild and moderate asthma.Journal of veterinary internal medicine · 2022Article
- Bronchial brush cytology, endobronchial biopsy, and SALSA immunohistochemistry in severe equine asthma.Veterinary pathology · 2022Article
- Changes in Acute-Phase Proteins in Plasma during the Periparturient Period of Dairy Goats.Veterinary sciences · 2021Article
- Exercise-induced airflow changes in horses with asthma measured by electrical impedance tomography.Journal of veterinary internal medicine · 2021Article
- Light and electron-microscopic localization of CD9 and surfactant protein A and D in normal lungs of the horse.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Glucocorticoid treatment in horses with asthma: A narrative review.Journal of veterinary internal medicine · 2021Review
- The Relationship between Lung Inflammation and Aerobic Threshold in Standardbred Racehorses with Mild-Moderate Equine Asthma.Animals : an open access journal from MDPI · 2020Article
- Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses.BMC veterinary research · 2020Article
- Equine Asthma: Current Understanding and Future Directions.Frontiers in veterinary science · 2020Review
- Investigation of blood biomarkers for the diagnosis of mild to moderate asthma in horses.Journal of veterinary internal medicine · 2019Article
- Clinical findings and outcome predictors for multinodular pulmonary fibrosis in horses: 46 cases (2009-2019).Journal of veterinary internal medicineArticle
- Use of inhaled ciclesonide for treatment of moderate asthma in Thoroughbred racehorses.Journal of veterinary internal medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
backgroundAsthma in horses is associated with nonspecific respiratory clinical signs and may be manifested only as exercise intolerance. Its diagnosis relies on bronchoalveolar lavage fluid (BALF) cytology in the presence of compatible clinical signs. The identification of blood biomarkers for this condition would facilitate diagnosis in the field, because there are regional areas where BAL is not routinely performed in clinical practice.
objectiveIdentification of blood biomarkers for the diagnosis of asthma in horses. ANIMALS: Fourteen horses with asthma with increased neutrophil numbers in BALF (neutrophilic asthma), 9 healthy control horses, and 10 horses with other pathologic conditions (pathologic controls).
methodsPhysical examination, clinical score, hematology, and BALF cytology (in a subset of horses) were performed. Serum concentrations of surfactant protein D (SP-D), haptoglobin, and secretoglobin (SCGB) were measured using commercial ELISA assays.
resultsSerum concentration of SP-D > 43 ng/mL, serum concentration of haptoglobin >5730 ng/mL, and serum concentration of SCGB <19 ng/mL allowed differentiation of horses with neutrophilic asthma from horses of the control groups (healthy and pathologic) with sensitivity of 55, 95, and 75%, and specificity of 67, 28, and 60%, respectively. Specificity of 100% and sensitivity of 45% were obtained with the combination of SP-D, haptoglobin, and SCGB at the serum concentrations indicated above. Specificity of 95% and sensitivity of 45% were obtained with the combination of SP-D and SCGB serum concentrations. CONCLUSIONS AND CLINICAL IMPORTANCE: Haptoglobin, SCGB, and SP-D may be diagnostic aids in horses with clinical signs of lower airway disease and neutrophilic pulmonary inflammation.
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