Evidence map›Paper›PMID 31098961›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2019

Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial.

Dwight E Moulin, Patricia K Morley-Forster, Zameer Pirani, Cathy Rohfritsch, Larry Stitt

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01669967 (The Role of Intravenous), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01669967 nacompletednot on this map

The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2011 to 2015Enrolled34ConditionsNeuropathic PainArmsLidocaine, Diphenhydramine
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Current Strategies for the Management of Painful Diabetic Neuropathy.Journal of diabetes science and technology · 2022
    Review
  10. Review
  11. Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Dwight E MoulinDepartment of Clinical Neurological Sciences and Oncology, Western University, London, ON, Canada. dwight.moulin@lhsc.on.ca.
Patricia K Morley-ForsterDepartment of Anesthesia and Perioperative Medicine, Western University, London, ON, Canada.
Zameer PiraniDepartment of Anesthesia and Perioperative Medicine, Western University, London, ON, Canada.
Cathy RohfritschLawson Health Research Institute, London, ON, Canada.
Larry StittStatistical Services, London, ON, Canada.
Western University · CALawson Health Research Institute · CAStatistics Canada · CA

Funding

Canadian Foundation for Innovation Grant # 7878
6 · The paper itself

Abstract

purposeNeuropathic pain, resulting from injury to the peripheral or central nervous system, is due to upregulation of aberrant sodium channels with neuronal hyperexcitability. Lidocaine blocks these channels and several studies show that intravenous (IV) lidocaine infusion provides significant relief in patients with chronic peripheral neuropathic pain in the short term (for up to six hours). Our objective was to determine if IV lidocaine provides significant pain relief and overall improvement in quality of life in the longer term (for up to four weeks).

methodsThis single site randomized double-blind, crossover trial compared IV lidocaine infusion (5 mg·kg

resultsWe enrolled 34 subjects in this trial-mostly with painful diabetic neuropathy and post-herpetic neuralgia. There were no significant differences between IV lidocaine and placebo infusions at any time point involving any of the outcome measures. Mean (standard deviation) pain intensity at week 4 for the placebo and lidocaine groups were not different [6.58 (1.97) vs 6.78 (1.56), respectively; between-group difference, 0.17; 95% confidence interval, - 0.50 to 0.84].

conclusionWe found no significant long-term analgesic or quality of life benefit from IV lidocaine relative to control infusion for chronic peripheral neuropathic pain.

trial registrationclinicaltrials.gov (NCT01669967); registered 22 June, 2012.

Indexed as

AgedAnesthetics, LocalChronic PainCross-Over StudiesDiabetic NeuropathiesDiphenhydramineDouble-Blind MethodFemaleHumansInfusions, IntravenousLidocaineMaleMiddle AgedNeuralgia, PostherpeticPain MeasurementPeripheral Nervous System DiseasesAnesthetics, LocalDiphenhydramineLidocaine

Identifiers

PMID31098961
OpenAlexW2945881504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.