ArticleJournal of neural transmission (Vienna, Austria : 1996)2019
Childhood adversity and parenting behavior: the role of oxytocin receptor gene polymorphisms.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Caregiver adverse childhood experiences and burden: associations with child welfare risk in a caregiver-child-sample.Frontiers in child and adolescent psychiatry · 2026Article
- Emotion regulation moderates between maternal adverse childhood experiences (ACEs) and oxytocin response.Archives of women's mental health · 2022Article
- A Systematic Review of the Effect of Parental Adverse Childhood Experiences on Parenting and Child Psychopathology.Journal of child & adolescent trauma · 2022Article
- Neurobiological Implications of Parent-Child Emotional Availability: A Review.Brain sciences · 2021Review
- How stress can influence brain adaptations to motherhood.Frontiers in neuroendocrinology · 2021Review
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research revealed experiences of childhood adversity (CA) to be related to less favorable parenting behavior. It can further be expected that maternal oxytocin receptor (OXTR) genes may influence parenting behavior and moderate relationships between CA and parenting behavior. Moreover, associations between the OXTR gene and plasma oxytocin (OT) have been discussed. The present study investigated main effects of the OXTR gene on parenting behavior and plasma OT of mothers, and moderating effects of the OXTR gene on the relationship between mothers' experiences of CA and parenting behavior. We relied on a sample of 193 mothers and their on average 8-year-old children. Maternal experiences of CA were assessed using a standardized interview. A questionnaire for the assessment of child abuse potential and observations of mother-child interaction were used as indicators of parenting behavior. For mothers, we analyzed three polymorphisms (rs53576, rs1042778, rs2254298) of the OXTR gene and plasma OT. Only the rs53576 was associated with mothers' parenting behavior, specifically with maternal sensitivity. The rs2254298 significantly moderated relations between mothers' experiences of CA and parenting behavior. Significant relations could be found only for mothers who were homozygous for the G allele. The G allele of the rs2254298 was further related to increased plasma OT levels. Our findings underline the importance of considering genetic variation when investigating consequences of CA and developing intervention programs that are adapted to an individual's needs.
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