ArticleEuropean journal of nutrition2020
Effects of maternal folic acid supplementation during pregnancy on infant neurodevelopment at 1 month of age: a birth cohort study in China.
Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.Frontiers in neuroscience · 2026Pooled it
- Predictors influencing neurodevelopment during the infancy of term infants.Frontiers in pediatrics · 2025Article
- Association of gestational cardiovascular health with infant neurodevelopment: A prospective study in Hefei of Anhui, China.Preventive medicine reports · 2024Article
- Advances in DNA methylation of imprinted genes and folic acid regulation of growth and development.Epigenomics · 2024Review
- Article
- Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review.Developmental psychobiology · 2023Article
- A Role for Data Science in Precision Nutrition and Early Brain Development.Frontiers in psychiatry · 2022Review
- Maternal and neonatal factors associated with child development in Ceará, Brazil: a population-based study.BMC pediatrics · 2021Article
- Maternal folate levels during pregnancy and children's neuropsychological development at 2 years of age.European journal of clinical nutrition · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThis study aimed to explore effects of maternal folic acid (FA) supplementation during pregnancy on neurodevelopment in 1-month-old infants and to determine whether effects may be related to maternal circulating inflammatory cytokine concentrations.
methodsThis birth cohort study recruited 1186 mother-infant pairs in Tianjin, China, between July 2015 and July 2017. The women completed interviewer-administered questionnaires on their lifestyles and FA supplementation during pregnancy. Neurodevelopment was assessed in 1-month-old infants using a standard neuropsychological examination table. In 192 women, serum homocysteine (Hcy) and inflammatory cytokine concentrations were measured at 16-18 weeks of gestation.
resultsThe infants whose mothers took FA supplements during pregnancy had a significantly higher development quotient (DQ) compared with those whose mothers were non-users (P < 0.05). After adjustment for maternal characteristics, supplementary FA use for 1-3 months, 3-6 months, and > 6 months were associated with the increases of 7.7, 11.0, and 7.4 units in the scale of infant DQ score compared with women reporting no supplement use, respectively (P < 0.05). FA supplementation was associated with a decreased serum concentration of Hcy (β = [Formula: see text] 0.19), which was correlated with women's serum inflammatory cytokine concentrations at 16-18 weeks of gestation (β = 0.57). Serum inflammatory cytokine concentrations were inversely related to DQ score in the 1-months-old offspring (β = [Formula: see text] 0.22).
conclusionsMaternal FA supplementation during pregnancy favors neurodevelopment in the offspring at 1-month-old. This association may be mediated by changes in serum Hcy and inflammatory cytokine concentrations throughout pregnancy.
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