ArticlemSystems
Social-Stress-Responsive Microbiota Induces Stimulation of Self-Reactive Effector T Helper Cells.
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice.Cell reports · 2023Pooled it
- Integrating gut microbiota and violence exposure metrics to classify psychological distress in middle-aged adults.Communications medicine · 2026Article
- The mouse gut microbiota responds to predator odor and predicts host behavior.bioRxiv : the preprint server for biology · 2025Article
- New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside.Journal of Zhejiang University. Science. B · 2025Review
- A gut (microbiome) feeling about addiction: Interactions with stress and social systems.Neurobiology of stress · 2024Review
- Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder.Frontiers in immunology · 2024Review
- Baseline gut microbiota profiles affect treatment response in patients with depression.Frontiers in microbiology · 2024Review
- Microbial underdogs: exploring the significance of low-abundance commensals in host-microbe interactions.Experimental & molecular medicine · 2023Review
- Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice.Microorganisms · 2022Article
- Effect of ProbioticNutrients · 2022Article
- Using the microbiome in clinical practice.Microbial biotechnology · 2022Article
- Ezh2 harnesses the intranuclear actin cytoskeleton to remodel chromatin in differentiating Th cells.iScience · 2021Article
- Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes.Microorganisms · 2021Article
- Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice.Scientific reports · 2021Article
- The human symbiont Mucispirillum schaedleri: causality in health and disease.Medical microbiology and immunology · 2021Review
- Examining the Role of Microbiota in Emotional Behavior: Antibiotic Treatment Exacerbates Anxiety in High Anxiety-Prone Male Rats.Neuroscience · 2021Article
- Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue.NPJ biofilms and microbiomes · 2021Article
- Gut Microbiome Dysbiosis and Depression: a Comprehensive Review.Current pain and headache reports · 2020Review
- Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Dysbiosis of the gut and lung microbiome has a role in asthma.Seminars in immunopathology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stressful life events are considered a risk factor for autoimmune disorders, though the mechanisms are unclear. Here we demonstrate that chronic social stress induces virulence-associated transcriptional patterns in the murine gut microbiota. The stress-influenced microbiota increased the presence of effector T helper cells in the mesenteric lymph nodes, including myelin-autoreactive cells. Inhibition of the bacterial quorum sensor QseC, which is also responsive to norepinephrine, diminished the presence of effector T helper cells and bacteria such as Acinetobacter in the mesenteric lymph nodes, without remarkably affecting the gut microbial composition. Together, our results delineate a model in which the immune reaction to stress-responsive microbiota may compromise tolerance to self and therefore may increase the risk for autoimmune diseases in susceptible individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.