Evidence map›Paper›PMID 31098334›Full record

ArticleQuantitative biology (Beijing, China)2018

Mapping transcriptome-wide protein-RNA interactions to elucidate RNA regulatory programs.

Molly M Hannigan, Leah L Zagore, Donny D Licatalosi

Abstract read
In one paragraph

Article in Quantitative biology (Beijing, China), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Unveiling ncRNA regulatory axes in atherosclerosis progression.Clinical and translational medicine · 2020
    Review
  9. Approaches for measuring the dynamics of RNA-protein interactions.Wiley interdisciplinary reviews. RNA · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Molly M Hannigan *Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, OH 44106, USA.
Leah L Zagore *Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, OH 44106, USA.
Donny D LicatalosiCenter for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, OH 44106, USA.

Funding

GRADUATE TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM008056 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI DIEHL, JOHN ALAN, SNIDER, MARTIN D · 1985 to 2019
$7.1M
Ptbp2 function and global mRNA regulation during mammalian cell developmentR01GM107331 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI LICATALOSI, DONNY D · 2013 to 2022
$2.8M
NIGMS NIH HHS R01 GM107331NIGMS NIH HHS T32 GM008056
6 · The paper itself

Abstract

backgroundOur understanding of post-transcriptional gene regulation has increased exponentially with the development of robust methods to define protein-RNA interactions across the transcriptome. In this review, we highlight the evolution and successful applications of crosslinking and immunoprecipitation (CLIP) methods to interrogate protein-RNA interactions in a transcriptome-wide manner.

resultsHere, we survey the vast array of

conclusionsIn summary, this review summarizes the benefits of characterizing RNA-protein networks to further understand the regulation of gene expression and disease pathogenesis. Our review comments on how future CLIP technologies can be adapted to address outstanding questions related to many aspects of RNA metabolism and further advance our understanding of RNA biology.

Indexed as

CLIPpost-transcriptional regulationRNA binding proteinsRNA networks

Identifiers

PMID31098334
PMCPMC6516777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.