Observational studyScientific reports2019
Mortality due to Cryptococcus neoformans and Cryptococcus gattii in low-income settings: an autopsy study.
Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Cryptococcosis-a systematic review to inform the World Health Organization Fungal Priority Pathogens List.Medical mycology · 2024Pooled it
- Feline Cryptococcosis: Two Case Reports and a Literature Review.Pathogens (Basel, Switzerland) · 2026Review
- Antimicrobial potential of a new Streptomyces species isolated from a brazilian tropical coastal shrubland.Antonie van Leeuwenhoek · 2025Article
- Web-Based Dashboard for Tracking Cryptococcosis-Related Deaths in Brazil (2000-2022).Tropical medicine and infectious disease · 2025Article
- Polyphosphatases have a polyphosphate-independent influence on the virulence ofInfection and immunity · 2025Article
- Host-membrane lipid composition controlsFrontiers in immunology · 2025Article
- Antifungal potential of Rhinacanthus nasutus extracts against the pathogenic fungus Cryptococcus neoformans.PloS one · 2025Article
- Frequency of fungal pathogens in autopsy studies of people who died with HIV in Africa: a scoping review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2024Article
- Vaccine Strategies for Cryptococcus neoformans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation inFrontiers in fungal biology · 2024Article
- Clinical Features of Cryptococcal Meningoencephalitis in HIV-Positive and -Negative Patients in a Resource-Limited Setting.Journal of fungi (Basel, Switzerland) · 2023Article
- Emerging and re-emerging fungal threats in Africa.Parasite immunology · 2023Review
- Pathogenic Drug Resistant Fungi: A Review of Mitigation Strategies.International journal of molecular sciences · 2023Review
- Searching for new antifungals for the treatment of cryptococcosis.Revista da Sociedade Brasileira de Medicina Tropical · 2023Review
- Article
- What's New inJournal of fungi (Basel, Switzerland) · 2022Review
- Sterylglucosides in Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- Diffuse Adrenal Gland and Pancreas Necrosis in a Patient with Disseminated Cryptococcosis-Case Report.Life (Basel, Switzerland) · 2022Article
- Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Loss to follow-up associated factors in patients with chronic pulmonary aspergillosis and its impact on the disease prognosis.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
27 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptococcosis is a major opportunistic infection and is one of the leading causes of death in adults living with HIV in sub-Saharan Africa. Recent estimates indicate that more than 130,000 people may die annually of cryptococcal meningitis in this region. Although complete diagnostic autopsy (CDA) is considered the gold standard for determining the cause of death, it is seldom performed in low income settings. In this study, a CDA was performed in 284 deceased patients from Mozambique (n = 223) and Brazil (n = 61). In depth histopathological and microbiological analyses were carried out in all cases dying of cryptococcosis. We determined the cryptococcal species, the molecular and sero-mating types and antifungal susceptibility. We also described the organs affected and reviewed the clinical presentation and patient management. Among the 284 cases included, 17 fatal cryptococcal infections were diagnosed. Cryptococcus was responsible for 16 deaths among the 163 HIV-positive patients (10%; 95%CI: 6-15%), including four maternal deaths. One third of the cases corresponded to C. gattii (VGI and VGIV molecular types, Bα and Cα strains) and the remaining infections typed were caused by C. neoformans var. Grubii (all VNI and Aα strains). The level of pre-mortem clinical suspicion was low (7/17, 41%), and 7/17 patients (41%) died within the first 72 hours of admission. Cryptococcosis was responsible for a significant proportion of AIDS-related mortality. The clinical diagnosis and patient management were inadequate, supporting the need for cryptococcal screening for early detection of the disease. This is the first report of the presence of C. gattii infection in Mozambique.
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