ArticleScientific reports2019
Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Auditory cellular cooperativity probed via spontaneous otoacoustic emissions.Biophysical journal · 2025Article
- Link between stimulus otoacoustic emissions fine structure peaks and standing wave resonances in a cochlear model.The Journal of the Acoustical Society of America · 2022Article
- Whistling While it Works: Spontaneous Otoacoustic Emissions and the Cochlear Amplifier.Journal of the Association for Research in Otolaryngology : JARO · 2022Review
- Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.Biophysical journal · 2021Article
- Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted.Scientific reports · 2021Article
- Nonlinear cochlear mechanics without direct vibration-amplification feedback.Physical review researchArticle
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The mammalian cochlea is able to detect faint sounds due to the presence of an active nonlinear feedback mechanism that boosts cochlear vibrations of low amplitude. Because of this feedback, self-sustained oscillations called spontaneous otoacoustic emissions (SOAEs) can often be measured in the ear canal. Recent experiments in genetically modified mice have demonstrated that mutations of the genes expressed in the tectorial membrane (TM), an extracellular matrix located in the cochlea, can significantly enhance the generation of SOAEs. Multiple untested mechanisms have been proposed to explain these unexpected results. In this work, a physiologically motivated computational model of a mammalian species commonly studied in auditory research, the gerbil, is used to demonstrate that altering the viscoelastic properties of the TM tends to affect the linear stability of the cochlea, SOAE generation and the cochlear response to low amplitude stimuli. These results suggest that changes in TM properties might be the underlying cause for SOAE enhancement in some mutant mice. Furthermore, these theoretical findings imply that the TM contributes to keeping the mammalian cochlea near an oscillatory instability, which promotes high sensitivity and the detection of low level stimuli.
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