Evidence map›Paper›PMID 31097732›Full record

Trial reportScientific reports2019

Complexity-Based Measures of Heart Rate Dynamics in Older Adults Following Long- and Short-Term Tai Chi Training: Cross-sectional and Randomized Trial Studies.

Yan Ma, Chiu-Wen Wu, Chung-Kang Peng, Andrew Ahn, Suzanne M Bertisch, Lewis A Lipsitz, Gloria Y Yeh, Brad Manor, Vera Novak, Jeffrey M Hausdorff and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Patterns of heart rate reduction during sleep onset in participants with and without insomnia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  4. The Science of Tai Chi andJournal of integrative and complementary medicine · 2025
    Review
  5. The impact of yoga on aging physiology: A review.The journal of nutrition, health & aging · 2024
    Review
  6. Day-night patterns in heart rate variability and complexity: differences with age and cardiopulmonary disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  7. Review
  8. Review
  9. Article
  10. Automatic classification of excitation location of snoring sounds.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yan MaDivision of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. dr.yan.ma@gmail.com.ORCID http://orcid.org/0000-0003-1173-2920
Chiu-Wen WuNational Taiwan Normal University, Department of Mechatronic Engineering, Taipei, Taiwan.
Chung-Kang PengDivision of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.ORCID http://orcid.org/0000-0003-3666-9833
Andrew AhnDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Suzanne M BertischDepartment of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Lewis A LipsitzDivision of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Gloria Y YehDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Brad ManorDivision of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Vera NovakDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Jeffrey M HausdorffCenter for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Brian GowDivision of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Peter M WayneOsher Center for Integrative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Research Training in Complementary and Integrative MedicineT32AT000051 · NCCIH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GLORIA Y YEH · 1999 to 2026
$10.2M
Health Outcomes of Tai Chi in Subsidized Senior HousingR01AG025037 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS, WAYNE, PETER MICHAEL · 2015 to 2019
$3.5M
Mentoring and Patient-Oriented Research in Mind-Body ExerciseK24AT009465 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GLORIA Y YEH · 2017 to 2026
$1.3M
Mentoring and research in mind-body and integrative therapiesK24AT009282 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI WAYNE, PETER MICHAEL · 2017 to 2021
$834k
Tai chi, physiologic complexity, and healthy agingR21AT005501 · NCCIH · HARVARD MEDICAL SCHOOL · PI WAYNE, PETER MICHAEL · 2010 to 2012
$733k
NCCIH NIH HHS K24 AT009282NCCIH NIH HHS K24 AT009465NCCIH NIH HHS R21 AT005501NCCIH NIH HHS T32 AT000051NCRR NIH HHS UL1 RR025758NIA NIH HHS R01 AG025037
6 · The paper itself

Abstract

Measures characterizing the complexity of heart rate (HR) dynamics have been informative in predicting age- and disease-related decline in cardiovascular health, but few studies have evaluated whether mind-body exercise can impact HR complexity. This study evaluated the effects of long-term Tai Chi (TC) practice on the complexity of HR dynamics using an observational comparison of TC experts and age- and gender-matched TC-naïve individuals. Shorter-term effects of TC were assessed by randomly assigning TC-naïve participants to either TC group to receive six months of TC training or to a waitlist control group. 23 TC experts (age = 63.3 ± 8.0 y; 24.6 ± 12.0 y TC experience) and 52 TC-naïve (age = 64.3 ± 7.7 y) were enrolled. In cross-sectional analyses, TC experts had a higher overall complexity index (CI, p = 0.004) and higher entropy at multiple individual time scales (p < 0.05); these findings persisted in models accounting for age, gender, body mass index (BMI), and physical activity levels. Longitudinal changes in complexity index did not differ significantly following random assignment to six months of TC vs. a waitlist control; however, within the TC group, complexity at select time scales showed statistically non-significant trends toward increases. Our study supports that longer-term TC mind-body training may be associated with increased complexity of HR dynamics.

Indexed as

Heart RateAgedAge FactorsBody Mass IndexFemaleHumansMaleMiddle AgedPhysical FitnessSex FactorsSystems AnalysisTai Ji

Identifiers

PMID31097732
PMCPMC6522618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.