ArticleScience (New York, N.Y.)2019
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 1 of them a synthesis that pooled it.
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188citing papers in PubMed, 1 pooled it
19.4field-weighted citation impact, top 1% of its field
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Who cites it
188 citing papers in PubMed, 1 synthesis or guideline pooled it, 333 citations in OpenAlex.
- Associations of adiposity and weight change with recurrence and survival in breast cancer patients: a systematic review and meta-analysis.Breast cancer (Tokyo, Japan) · 2022Pooled it
- 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial.Carcinogenesis · 2020Trial
- Integrated Bioinformatics and Experimental Validation of Post-Translational Modification-Related Biomarkers in Myocardial Ischemia-Reperfusion Injury.Journal of cardiovascular translational research · 2026Article
- LL-37 inhibits osteosarcoma progression by suppressing SQLE-mediated cholesterol synthesis via the PTEN/AKT/mTOR pathway.Journal of bone oncology · 2026Article
- BoOFP6 Negatively Regulates Glucosinolates Accumulation in Broccoli Sprouts by Cytoplasmic Sequestration of BoMYB34-3.Plant, cell & environment · 2026Article
- Fluorofenidone ameliorates pressure overload-induced heart failure by stabilizing SERCA2a in male mice.Nature communications · 2026Article
- SARS-CoV-2 ORF3a suppresses host antiviral interferon responses by promoting STUB1-mediated PTEN proteasomal degradation.Journal of virology · 2026Article
- E2F-mediated activation of mTORC1 through the ubiquitin-proteasome system promotes lung adenocarcinoma progression.Cell death & disease · 2026Article
- Identification and validation of an interaction between the E3 ubiquitin ligase WWP1 and the Transcriptional Co-Activator WBP2 in the human heart.Biology open · 2026Article
- HECT ubiquitin ligases as regulators of inflammatory signalling.Cell death and differentiation · 2026Review
- WWP1 gain-of-function drives developmental anoikis through TGFβ pathway during neurodevelopment.Cell death discovery · 2026Article
- Involvement of c-Myc/WWP1/TRIM65 Axis in Renal Fibrosis.Biomolecules · 2026Article
- Deciphering molecular pathways in urological cancers: A gateway to precision therapeutics.Journal of advanced research · 2026Review
- Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia.Science translational medicine · 2026Article
- Indole-3-carbinol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway.Journal of ovarian research · 2026Article
- Serotonergic System-Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Targeting WWPI HECT Domain by Small Inhibitors for Restoring PTEN Tumor Suppressive Role in Glioblastoma Therapy.Anti-cancer agents in medicinal chemistry · 2026Article
- Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer.International journal of genomics · 2026Article
- Targeting ubiquitination in disease and therapy.Signal transduction and targeted therapy · 2025Review
- Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells.Annals of medicine · 2025Article
128 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 5 countries.
Yu-Ru LeeCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-6592-6806
Ming ChenCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-3470-1062
Jonathan D Lee *Cancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.
Jinfang Zhang *Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Shu-Yu Lin *Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
Tian-Min FuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6281-1752
Hao ChenDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-2534-9650
Tomoki IshikawaCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.
Shang-Yin ChiangInstitute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
Jesse KatonCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-4551-0648
Yang ZhangCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.
Yulia V ShulgaCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-5092-0727
Assaf C BesterCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.
Jacqueline FungCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.
Emanuele MonteleoneCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-7440-900X
Lixin WanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9759-5113
Chen ShenDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Chih-Hung HsuDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8071-0122
Antonella PapaCancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.ORCID 0000-0001-8653-7121
John G ClohessyCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-5186-9775
Julie Teruya-FeldsteinDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Suresh JainIntonation Research Laboratories, Hyderabad, India.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7281-8579
Lydia MatesicDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-6460-2321
Ruey-Hwa ChenInstitute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
Wenyi WeiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0512-3811
Pier Paolo PandolfiCancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, USA. ppandolf@bidmc.harvard.edu.ORCID 0000-0002-5352-5295
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · USNational Taiwan University · TWIcahn School of Medicine at Mount Sinai · USInstitute of Biological Chemistry, Academia Sinica · TWMonash University · AUUniversity of South Carolina · US
Funding
PTEN IN ONTOGENESIS AND TUMOR SUPPRESSIONR01CA082328 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PANDOLFI, PIER PAOLO · 1999 to 2015
$5.3MTargeting Tumor Suppressive Pathways for Cancer TherapyR35CA197529 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PANDOLFI, PIER PAOLO · 2015 to 2019
$4.6MTargeting the APC/Cdc20 E3 ubiquitin ligase for chemoradiation sensitizationR01CA200651 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEI, WENYI · 2016 to 2020
$1.9MIntracellular Sorting of Connexin 43 by the Ubiquitin Ligase Wwp1R01HL104030 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MATESIC, LYDIA ELEANOR · 2010 to 2014
$1.7MNCI NIH HHS R01 CA082328NCI NIH HHS R01 CA200651NCI NIH HHS R35 CA197529NHLBI NIH HHS R01 HL104030
Abstract
Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusive, strategy. PTEN is a critical tumor suppressive phosphatase that is active in its dimer configuration at the plasma membrane. Polyubiquitination by the ubiquitin E3 ligase WWP1 (WW domain-containing ubiquitin E3 ligase 1) suppressed the dimerization, membrane recruitment, and function of PTEN. Either genetic ablation or pharmacological inhibition of WWP1 triggered PTEN reactivation and unleashed tumor suppressive activity.
Indexed as
Anticarcinogenic AgentsCarcinogenesisHEK293 CellsHumansIndolesMaleNeoplasmsProtein MultimerizationProto-Oncogene MasProto-Oncogene Proteins c-mycPTEN PhosphohydrolaseTumor Suppressor ProteinsUbiquitinationUbiquitin-Protein LigasesAnticarcinogenic Agentsindole-3-carbinolIndolesMAS1 protein, humanMYC protein, humanProto-Oncogene MasProto-Oncogene Proteins c-mycPTEN PhosphohydrolasePTEN protein, humanTumor Suppressor ProteinsUbiquitin-Protein LigasesWWP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.