Evidence map›Paper›PMID 31097580›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Pierre Montay-Gruel, Munjal M Acharya, Kristoffer Petersson, Leila Alikhani, Chakradhar Yakkala, Barrett D Allen, Jonathan Ollivier, Benoit Petit, Patrik Gonçalves Jorge, Amber R Syage and 12 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 286 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed, 6 pooled it
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

286 citing papers in PubMed, 6 syntheses or guidelines pooled it, 571 citations in OpenAlex.

  1. Pooled it
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  6. The current status of FLASH particle therapy: a systematic review.Physical and engineering sciences in medicine · 2023
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  13. Reduced corneal toxicity following whole brain irradiation in mice.Clinical and translational radiation oncology · 2026
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226 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 2 countries.

Pierre Montay-GruelLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Munjal M AcharyaDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Kristoffer PeterssonLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Leila AlikhaniDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Chakradhar YakkalaLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Barrett D AllenDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Jonathan OllivierLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Benoit PetitLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Patrik Gonçalves JorgeLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Amber R SyageDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Thuan A NguyenDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Al Anoud D BaddourDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Celine LuDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Paramvir SinghDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695.
Raphael MoeckliInstitute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
François BochudInstitute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Jean-François GermondInstitute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Pascal FroidevauxInstitute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Claude BailatInstitute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Jean BourhisLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland.
Marie-Catherine VozeninLaboratory of Radiation Oncology, Lausanne University Hospital, University of Lausanne, Lausanne VD-1011, Switzerland; marie-catherine.vozenin@chuv.ch climoli@uci.edu.
Charles L LimoliDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695; marie-catherine.vozenin@chuv.ch climoli@uci.edu.ORCID 0000-0002-1321-4142
University of Lausanne · CHUniversity of California, Irvine · US

Funding

Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
Mechanisms underlying radiation-and chemotherapy induced cognitive impairment.R01NS089575 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2015 to 2020
$2.8M
NCATS NIH HHS KL2 TR001416NINDS NIH HHS R01 NS089575
6 · The paper itself

Abstract

Here, we highlight the potential translational benefits of delivering FLASH radiotherapy using ultra-high dose rates (>100 Gy⋅s

Indexed as

Cognitive DysfunctionRadiation DosageAnimalsBrainFemaleInflammationMiceMice, Inbred C57BLNeuroprotectionRadiotherapyReactive Oxygen SpeciesReactive Oxygen Speciescognitive dysfunctionneuroinflammationneuronal morphologyreactive oxygen speciesultra-high dose-rate irradiation

Identifiers

PMID31097580
PMCPMC6561167
OpenAlexW2946753897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.