Evidence map›Paper›PMID 31097578›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model.

Suhasini R Gopal, Yvonne T Lee, Ruben Stepanyan, Brian M McDermott, Kumar N Alagramam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Suhasini R GopalDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Yvonne T LeeDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Ruben StepanyanDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Brian M McDermottDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.ORCID 0000-0002-2450-1999
Kumar N AlagramamDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106; kna3@case.edu.
University Hospitals of Cleveland · US

Funding

Elucidating theMolecular Mechanisms that Shape the Hair BundleR01DC009437 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI MCDERMOTT, BRIAN MICHAEL · 2009 to 2019
$4.3M
Mechanotransduction and calcium regulation in cochlear hair cellsR01DC015016 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI STEPANYAN, RUBEN · 2016 to 2020
$1.7M
Acquisition of a Leica TCS SP5 Confocal Microscope For A Multi-User FacilityS10OD016164 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CONRAD, PATRICIA A · 2013 to 2013
$597k
Deciphering the Role of the Clarin Gene Family in the EarR03DC015621 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI GOPAL, SUHASINI R. · 2016 to 2018
$467k
NIDCD NIH HHS R01 DC009437NIDCD NIH HHS R01 DC015016NIDCD NIH HHS R03 DC015621NIH HHS S10 OD016164
6 · The paper itself

Abstract

The pathogenic variant c.144T>G (p.N48K) in the clarin1 gene (

Indexed as

Membrane ProteinsAnimalsAnimals, Genetically ModifiedArtemisininsHair Cells, AuditoryMechanotransduction, CellularSecretory PathwayZebrafishartemisininArtemisininsCLRN1 protein, humanMembrane Proteinshearing lossmitigationUSH3A

Identifiers

PMID31097578
PMCPMC6561152
OpenAlexW2945375966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.