ArticleBiological psychiatry2019
Striatal Dopamine Release in Response to Morphine: A [
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards.Psychological medicine · 2023Trial
- Brixadi for Stimulant Use Disorder: Evolving Pharmacologic Considerations and Clinical Implications.Advances in therapy · 2026Review
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Differential acquisition of cocaine and heroin self-administration in a rat model of internalizing versus externalizing temperament.bioRxiv : the preprint server for biology · 2026Article
- Analysis of clinical trials on drugs targeting dopamine receptors: a scoping review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Oxytocin Reduces Methylphenidate-Induced Dorsal Striatal Dopamine Release in Male Rhesus Macaques.The international journal of neuropsychopharmacology · 2024Article
- Article
- Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder.Trends in neurosciences · 2024Review
- Article
- Heroin and its metabolites: relevance to heroin use disorder.Translational psychiatry · 2023Review
- Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine.Human brain mapping · 2022Article
- Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail.Frontiers in pharmacology · 2022Review
- Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum.Translational psychiatry · 2021Article
- Naloxone precipitated withdrawal increases dopamine release in the dorsal striatum of opioid dependent men.Translational psychiatry · 2021Article
- Dopamine 'ups and downs' in addiction revisited.Trends in neurosciences · 2021Review
- Mindful Positive Emotion Regulation as a Treatment for Addiction: From Hedonic Pleasure to Self-Transcendent Meaning.Current opinion in behavioral sciences · 2021Article
- Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Article
- Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Epigenetic Mechanisms of Opioid Addiction.Biological psychiatry · 2020Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPreclinical and human positron emission tomography studies have produced inconsistent results regarding the effects of opioids on mesolimbic dopamine (DA). Here, we quantify striatal DA release (measured by [
methodsFifteen healthy male participants were initially included. Sessions were on separate days. On session 1, participants received intravenous morphine (10 mg/70 kg) in the clinic to ensure tolerability. Participants without adverse reactions (n = 10) then received intravenous morphine and placebo (saline) sessions, in counterbalanced order, while undergoing [
resultsMorphine produced marked subjective and physiological effects and induced a significant decrease in [
conclusionsThis is, to our knowledge, the first study providing in vivo human evidence that DA transmission in the ventral striatum is affected by morphine. Further studies are required to fully delineate the DA contribution to the reinforcing effects of opioids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.