ArticleAlzheimer's research & therapy2019
The association of vascular disorders with incident dementia in different age groups.
Article in Alzheimer's research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Guideline
- Associations between heart failure and risk of dementia: A PRISMA-compliant meta-analysis.Medicine · 2020Pooled it
- Timing and duration of diabetes and incident dementia in older adults: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Dementia Risk in the Decade Before and After Coronary Heart Disease Diagnosis: Hybrid Case-Control and Cohort Study.Journal of the American Heart Association · 2026Article
- Updates on vascular dementia.Stroke and vascular neurology · 2025Review
- Associations of early-onset coronary heart disease and genetic susceptibility with incident dementia and white matter hyperintensity: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Polygenic risk scores for atrial fibrillation and heart failure and the risk of stroke and dementia.Brain communications · 2025Article
- Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review.Genes · 2024Article
- Metabolic-Associated Fatty Liver Disease and Cognitive Performance in Type 2 Diabetes: Basal Data from the Phytate, Neurodegeneration and Diabetes (PHYND) Study.Biomedicines · 2024Article
- Neuropathologic Burden and Dementia in Nonagenarians and Centenarians: Comparison of 2 Community-Based CohortsNeurology · 2024Article
- Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study.Journal of the American Heart Association · 2023Article
- Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study.BMC geriatrics · 2023Article
- Association between cardiovascular diseases and dementia among various age groups: a population-based cohort study in older adults.Scientific reports · 2023Article
- Associations between non-alcoholic fatty liver disease and cognitive impairment and the effect modification of inflammation.Scientific reports · 2022Article
- BMI and Allostatic Load Are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light among Urban Middle-Aged Adults.The Journal of nutrition · 2022Article
- Association of Cardiovascular Health Metrics with Dementia in Rural Chinese Older Adults: A Population-Based Study.Clinical interventions in aging · 2022Article
- Association of cardiovascular disease and traditional cardiovascular risk factors with the incidence of dementia among patients with rheumatoid arthritis.Seminars in arthritis and rheumatism · 2021Article
- Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity.Frontiers in aging neuroscience · 2021Article
- Predictors of Dementia in the Oldest Old: A Novel Machine Learning Approach.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThere is increasing evidence that dementia risk associated with vascular disorders is age dependent. Large population-based studies of incident dementia are necessary to further elucidate this effect. Therefore, the aim of the present study was to determine the association of vascular disorders with incident dementia in different age groups in a large primary care database.
methodsWe included 442,428 individuals without dementia aged ≥ 65 years from the longitudinal primary care Integrated Primary Care Information (IPCI) database. We determined in 6 age groups (from 65-70 to ≥ 90 years) the risk of hypertension, diabetes mellitus, dyslipidemia, stroke, myocardial infarction, heart failure, and atrial fibrillation for all-cause dementia using incidence rate ratios, Cox regression, and Fine and Gray regression models.
resultsThe mean age at inclusion of the total study sample was 72.4 years, 45.7% of the participants were male, and median follow-up was 3.6 years. During 1.4 million person-years of follow-up, 13,511 individuals were diagnosed with dementia. The risk for dementia decreased with increasing age for all risk factors and was no longer significant in individuals aged ≥ 90 years. Adjusting for mortality as a competing risk did not change the results.
conclusionsWe conclude that vascular disorders are no longer a risk factor for dementia at high age. Possible explanations include selective survival of individuals who are less susceptible to the negative consequences of vascular disorders and differences in follow-up time between individuals with and without a vascular disorder. Future research should focus on the identification of other risk factors than vascular disorders, for example, genetic or inflammatory processes, that can potentially explain the strong age-related increase in dementia risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.