Observational studyCritical care (London, England)2019
Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study.
Observational study in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients: Pathophysiological Determinants, and Relation to Changes in Systemic, Regional and Microcirculatory Blood Flow
Timing of Preload Responsiveness in Sepsis and Septic Shock
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades.Critical care (London, England) · 2022Pooled it
- Comparison of oral water ingestion and intravenous fluid infusion on fluid responsiveness in healthy volunteers, a prospective, randomized trial.Scientific reports · 2026Trial
- Agreement between manual and automatic ultrasound measurement of the velocity-time integral in the left ventricular outflow tract in intensive care patients: evaluation of the AUTO-VTI® tool.Journal of clinical monitoring and computing · 2025Trial
- Optimizing Fluid Management Guided by Volumetric Parameters in Patients with Sepsis and ARDS.International journal of molecular sciences · 2023Trial
- Comparison of 5% human albumin and normal saline for fluid resuscitation in sepsis induced hypotension among patients with cirrhosis (FRISC study): a randomized controlled trial.Hepatology international · 2021Trial
- Morphological changes in the arterial pressure waveform following hemodynamic therapies in critical care: A clinical proof-of-concept study in older adults.Physiological reports · 2026Observational
- The usual suspects: a pragmatic framework to identify and address reversible contributors in apparent refractory septic shock.Critical care (London, England) · 2026Review
- Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).Intensive care medicine · 2026Article
- Data-driven spatial-temporal framework for exploring the heterogeneity and temporality of sepsis.Chinese medical journal · 2026Review
- Bedside thoracic echography in ICU: new insights for acute circulatory and respiratory failure.Intensive care medicine · 2026Review
- The time course of fluid responsiveness.Annals of intensive care · 2026Review
- Venous congestion from a vascular waterfall perspective: reframing congestion as a dynamic Starling resistor phenomenon.Intensive care medicine experimental · 2025Review
- End-tidal carbon dioxide changes induced by passive leg raising can predict fluid responsiveness in patients on veno-arterial extracorporeal membrane oxygenation: a prospective, interventional study.Annals of intensive care · 2025Article
- From Fluid Responsiveness to Prognosis: The Emerging Role of Point-of-Care Echocardiography in Sepsis.Diagnostics (Basel, Switzerland) · 2025Review
- Minimally-Invasive Imaging of Sublingual Vessels-A New Method to Study Microvascular Changes in Mice.Life (Basel, Switzerland) · 2025Article
- Passive leg raising test versus rapid fluid challenge in critically ill medical patients.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Article
- Non-invasive point-of-care optical technique for continuous in vivo assessment of microcirculatory function: Application to a preclinical model of early sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Critical Care Ultrasound in Shock: A Comprehensive Review of Ultrasound Protocol for Hemodynamic Assessment in the Intensive Care Unit.Journal of clinical medicine · 2024Review
- Hemodynamic Support in Sepsis.Anesthesiology · 2024Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion or 20 min later could affect the results of the FC.
methodsThis is a prospective, observational, multicenter study including all ICU patients in septic shock requiring a FC of 500 mL crystalloids over 10 min. Fluid responsiveness was defined as a > 15% increase in stroke volume (SV) assessed by velocity-time integral (VTI) measurements at baseline (T
resultsFrom May 20, 2014, to January 7, 2016, a total of 143 patients were enrolled in 11 French ICUs (mean age 64 ± 14 years, median IGS II 53 [43-63], median SOFA score 10 [8-12]). Among the 76/143 (53%) patient responders to FC at T
conclusionsThis study shows that 51.3% of initial responders have a persistent response to fluid 30 min after the beginning of fluid infusion and only 41.3% have a transient response highlighting that fluid responsiveness is time dependent.
trial registrationClinicalTrials.gov , NCT02116413 . Registered on April 16, 2014.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.