Evidence map›Paper›PMID 31096985›Full record

ArticleMalaria journal2019

Malaria impact on cognitive function of children in a peri-urban community in the Brazilian Amazon.

Raquel Tapajós, Daniel Castro, Gisely Melo, Seyi Balogun, Mark James, Rockson Pessoa, Anne Almeida, Mônica Costa, Rosemary Pinto, Bernardino Albuquerque and 4 more

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Non-cerebral malaria: does such a thing exist?Memorias do Instituto Oswaldo Cruz · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Malaria Related Neurocognitive Deficits and Behavioral Alterations.Frontiers in cellular and infection microbiology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Raquel TapajósFundação de Vigilância em Saúde do Amazonas, Manaus, Brazil.
Daniel CastroFundação de Vigilância em Saúde do Amazonas, Manaus, Brazil.
Gisely MeloFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Seyi BalogunKent University, Kent, OH, USA.
Mark JamesKent University, Kent, OH, USA.
Rockson PessoaEscola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Brazil.
Anne AlmeidaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Mônica CostaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Rosemary PintoFundação de Vigilância em Saúde do Amazonas, Manaus, Brazil.
Bernardino AlbuquerqueFundação de Vigilância em Saúde do Amazonas, Manaus, Brazil.
Wuelton MonteiroFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
José BragaEscola Nacional de Saúde Pública Sérgio Arouca, FIOCRUZ, Rio de Janeiro, Brazil.
Marcus LacerdaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil. marcuslacerda.submissao@gmail.com.
Maria Paula MourãoFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Fundação de Medicina Tropical · BREscola Superior de Ciências da Saúde · BRKent State University · USEscola Nacional de Saúde Pública · BRFundação Oswaldo Cruz · BRUniversidade do Estado do Amazonas · BR

Funding

SUBTHRESHOLD MUSCLE AFFERENT INPUT TO DORSAL HORNF06TW002012 · FIC · UNIVERSITY OF CALIFORNIA DAVIS · PI KAUFMAN, MARC PETER · 1995 to 1995
–
Conselho Nacional de Desenvolvimento Científico e Tecnológico 486989/2012-7
6 · The paper itself

Abstract

backgroundIn Latin America, where Plasmodium vivax malaria is more prevalent, it is known that this species plays an important role in the sustainability of transmission, and can have an impact on morbidity in terms of anaemia, nutritional status, and cognitive development in children.

methodsThe present study aimed to assess the impact of malaria infection on cognition of children in a peri-urban community in the Brazilian Amazon with moderate endemicity by applying Home Inventory and WPPSI-IV. A non-concurrent cohort study was designed and the cognitive, haematological, and nutritional profiles of the children were assessed. Children with documented malaria history were identified from official reported data.

resultsA total of 219 children aged between 2 and 7 years were enrolled. Although 205 (95%) children had normal birth weight, 177 (81%) were malnourished, and 35 (16%) had anaemia. Among the 100 (46%) children who experienced at least one episode of malaria, 89 (89%) children demonstrated low level of cognitive development. The findings showed that Plasmodium vivax malaria was an independent risk factor for low cognitive development.

conclusionsIn addition to the known economic impact of malaria in the Amazon region, the study highlights the deleterious effects P. vivax malaria has on the socio-cultural development of the population.

Indexed as

CognitionAnemiaBrazilChildChild, PreschoolCohort StudiesFemaleHumansInfantMalaria, VivaxMaleMalnutritionMorbidityPlasmodium vivaxPrevalenceRisk FactorsChildrenCognitionMalariaPlasmodium vivax

Identifiers

PMID31096985
PMCPMC6524266
OpenAlexW2947406061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.