ArticleBMC microbiology2019
Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols.
Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols.Marine drugs · 2025Review
- Whole-genome assembly and comparative genomic analyses provide insight into the endophytic lifestyle of Trichoderma lixii.Current genetics · 2025Article
- Exploring the Bioactive Secondary Metabolites of Two ArgentineJournal of fungi (Basel, Switzerland) · 2025Article
- Evaluation of cellulase production by endophytic fungi isolated from young and mature leaves of medicinal plants using maize cob substrate.Scientific reports · 2025Article
- Chemical Constituents and Anticancer Activities of Marine-Derived FungusMolecules (Basel, Switzerland) · 2024Article
- EndophyticFrontiers in microbiology · 2023Article
- Peptaibol Production and Characterization fromJournal of fungi (Basel, Switzerland) · 2022Article
- Exploring Peptaibol's Profile, Antifungal, and Antitumor Activity of Emericellipsin A ofMolecules (Basel, Switzerland) · 2022Article
- Deciphering the role of endophytic microbiome in postharvest diseases management of fruits: Opportunity areas in commercial up-scale production.Frontiers in plant science · 2022Review
- Rare Glutamic Acid Methyl Ester Peptaibols fromInternational journal of molecular sciences · 2021Article
- Peptaibol-Containing Extracts ofMolecules (Basel, Switzerland) · 2021Article
- The Emericellipsins A-E from an Alkalophilic FungusJournal of fungi (Basel, Switzerland) · 2021Article
- 14-Residue peptaibol velutibol A fromRSC advances · 2020Article
- Genome Sequence ofMicroorganisms · 2020Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundExploration of microbes isolated from north western Himalayas for bioactive natural products.
resultsA strain of Trichoderma lixii (IIIM-B4) was isolated from Bacopa monnieri L. The ITS based rDNA gene sequence of strain IIIM-B4 displayed 99% sequence similarity with different Trichoderma harzianum species complex. The highest score was displayed for Hypocrea lixii strain FJ462763 followed by H. nigricans strain NBRC31285, Trichoderma lixii strain CBS 110080, T. afroharzianum strain CBS124620 and Trichoderma guizhouense BPI:GJS 08135 respectively. Position of T. lixii (IIIM-B4) in phylogenetic tree suggested separate identity of the strain. Microbial dynamics of T. lixii (IIIM-B4) was investigated for small peptides. Medium to long chain length peptaibols of 11 residue (Group A), 14 residue (Group B) and 17 residue (Group C) were identified using Matrix Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) mass spectrometer. Optimization is undeniably a desideratum for maximized production of desirable metabolites from microbial strain. Here optimization studies were carried out on T. lixii (IIIM-B4) using different growth media through Intact Cell Mass Spectrometry (ICMS). A multifold increase was obtained in production of 11 residue peptaibols using rose bengal medium. Out of these, one of them named as Tribacopin AV was isolated and sequenced through mass studied. It was found novel as having unique sequence Ac-Gly-Leu-Leu-Leu-Ala-Leu-Pro-Leu-Aib-Val-Gln-OH. It was found to have antifungal activity against Candida albicans (25 μg/mL MIC).
conclusionIn this study, we isolated a strain of T. lixii (IIIM-B4) producing medium and long chain peptaibols. One of them named as Tribacopin AV was found novel as having unique sequence Ac-Gly-Leu-Leu-Leu-Ala-Leu-Pro-Leu-Aib-Val-Gln-OH, which had antifungal properties.
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