Evidence map›Paper›PMID 31096840›Full record

ArticleCell adhesion & migration2019

Platelet endothelial aggregation receptor-1 regulates bovine muscle satellite cell migration and differentiation via integrin beta-1 and focal adhesion kinase.

Yusheng Pang, Ziheng Zhang, Zhao Wang, Yuxin Wang, Yunqin Yan, Shufeng Li, Huili Tong

Open access · goldAbstract read
In one paragraph

Article in Cell adhesion & migration, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yusheng Panga The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Ziheng Zhanga The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Zhao Wanga The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Yuxin Wanga The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Yunqin Yana The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Shufeng Lia The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Huili Tonga The Laboratory of Cell and Developmental Biology , Northeast Agricultural University , Harbin , Heilongjiang , China.
Northeast Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpression and decreased upon its suppression. Meanwhile, we found that, upon PEAR1 induction, both the expression of the focal adhesion-associated and MyoG, and the myotube fusion rate increased. However, when PEAR1 was suppressed, opposite results were obtained. Immunoprecipitation revealed an association between PEAR1 and ITGB1. Notably, inhibition of FAK and ITGB1 repressed cell differentiation. In conclusion, our study indicated that PEAR1 is involved in the regulation of bovine MDSC migration and differentiation.

Indexed as

Cell DifferentiationCell MovementAnimalsCattleCells, CulturedFocal Adhesion Kinase 1Focal AdhesionsIntegrin beta1MyoblastsPhosphorylationPlatelet AggregationReceptors, Cell SurfaceSatellite Cells, Skeletal MuscleSignal TransductionFocal Adhesion Kinase 1Integrin beta1Receptors, Cell Surfacedifferentiationfocal adhesion kinaseintegrin beta-1migrationPEAR1

Identifiers

PMID31096840
PMCPMC6550786
OpenAlexW2946415858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.