Evidence map›Paper›PMID 31096818›Full record

ArticleThe Journal of international medical research2019

Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model.

Yang Liu, Yang Jiao, Yuxiang He, Xiangjiu Ding, Qingbo Su, Yan Zhao, Jianjun Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang Liu1 Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yang Jiao2 Department of General Surgery, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, China.
Yuxiang He3 Department of Vascular Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Xiangjiu Ding1 Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Qingbo Su1 Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yan Zhao1 Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Jianjun Jiang1 Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0002-6722-1268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDiabetes mellitus (DM) attenuates the development of aortic aneurysms (AA). This study investigated the expression of cathepsin L and cystatin C in a hyperglycemic environment, and the influence of these proteins on AA development.

methodsMice were divided into AA and DM+AA groups ( n=30 per group). DM was induced by injection of streptozotocin; AA was induced by injection of angiotensin II. Doppler examination was used to measure aortic diameter, and Weigert's elastic stain was used to detect elastin degradation. Cathepsin L and cystatin C in aortic tissue were examined by western blotting, immunohistochemistry, and polymerase chain reaction.

resultsAortic diameter in the DM+AA group was less than that in the AA group, and elastin fragmentation grade of the aortic wall was reduced in the DM+AA group. More cathepsin L-positive cells were observed in the AA group than in the DM+AA group; conversely, more cystatin C-positive cells were observed in the DM+AA group than in the AA group. Both protein and mRNA levels of cathepsin L and cystatin C showed similar trends to those observed in immunohistochemistry.

conclusionsExpression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with AA development in a mouse model.

Indexed as

Disease Models, AnimalAnimalsAortic AneurysmBiomarkersCathepsin LCystatin CDiabetes Mellitus, ExperimentalHyperglycemiaMaleMiceMice, Inbred C57BLMice, Knockout, ApoEBiomarkersCathepsin LCst3 protein, mouseCtsl protein, mouseCystatin Cangiotensin IIaortic aneurysmcathepsin Lcystatin Cdiabetes mellituselastinHyperglycemiamicestreptozocin

Identifiers

PMID31096818
PMCPMC6567726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.