Evidence map›Paper›PMID 31096669›Full record

ReviewMolecules (Basel, Switzerland)2019

Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery.

Iwona Stanislawska, Wioletta Liwinska, Marek Lyp, Zbigniew Stojek, Ewelina Zabost

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Epigenetic Control of a Local Chromatin Landscape.International journal of molecular sciences · 2020
    Review
  7. Bioactive Molecules and Their Mechanisms of Action.Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iwona StanislawskaDepartment of Nutrition, College of Rehabilitation, Kasprzaka 49, 01-234 Warsaw, Poland. iwona.stanislawska@wsr.edu.pl.
Wioletta LiwinskaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. wliwinska@chem.uw.edu.pl.
Marek LypDepartment of Nutrition, College of Rehabilitation, Kasprzaka 49, 01-234 Warsaw, Poland. marek.lyp@wsr.edu.pl.
Zbigniew StojekFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. stojek@chem.uw.edu.pl.
Ewelina ZabostFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. ezabost@chem.uw.edu.pl.ORCID 0000-0003-4544-6033

Funding

Narodowe Centrum Nauki 2015/19/N/ST5/03672
6 · The paper itself

Abstract

Recently, the fast development of hybrid nanogels dedicated to various applications has been seen. In this context, nanogels incorporating biomolecules into their nanonetworks are promising innovative carriers that gain great potential in biomedical applications. Hybrid nanogels containing various types of biomolecules are exclusively designed for: improved and controlled release of drugs, targeted delivery, improvement of biocompatibility, and overcoming of immunological response and cell self-defense. This review provides recent advances in this rapidly developing field and concentrates on: (1) the key physical consequences of using hybrid nanogels and introduction of biomolecules; (2) the construction and functionalization of degradable hybrid nanogels; (3) the advantages of hybrid nanogels in controlled and targeted delivery; and (4) the analysis of the specificity of drug release mechanisms in hybrid nanogels. The limitations and future directions of hybrid nanogels in targeted specific- and real-time delivery are also discussed.

Indexed as

Drug Delivery SystemsAnimalsBiocompatible MaterialsBiophysical PhenomenaBiopolymersDiffusionDrug CarriersDrug LiberationElasticityGelsHumansHydrogelsHydrogen-Ion ConcentrationMolecular StructureNanostructuresOligonucleotidesBiocompatible MaterialsBiopolymersDrug CarriersGelsHydrogelsOligonucleotidesProteinsbiomolecule–hydrogel nanocompositescontrolled releasedrug delivery systemshigh-drug loadinghybrid nanogelson–off systemsremotely controlled releasesmart materialstargeted delivery

Identifiers

PMID31096669
PMCPMC6572277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.