ReviewJournal of clinical medicine2019
Newly Generated and Non-Newly Generated "Immature" Neurons in the Mammalian Brain: A Possible Reservoir of Young Cells to Prevent Brain Aging and Disease?
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Immature Neurons in the Postnatal Brain: Markers, Modulation, and Involvement in Normal and Aberrant Plasticity.International journal of molecular sciences · 2026Review
- Article
- Article
- Review
- Postnatal plasticity in the olfactory system of the juvenile swine brain.Brain structure & function · 2025Article
- Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates.PLoS biology · 2025Article
- Adult neurogenesis and "immature" neurons in mammals: an evolutionary trade-off in plasticity?Brain structure & function · 2024Review
- Evidence for Two Subpopulations of Cerebrospinal Fluid-Contacting Neurons with Opposite GABAergic Signaling in Adult Mouse Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala.Neuron · 2024Article
- Adult human neurogenesis: A view from two schools of thought.IBRO neuroscience reports · 2023Review
- Consistency and Variation in Doublecortin and Ki67 Antigen Detection in the Brain Tissue of Different Mammals, including Humans.International journal of molecular sciences · 2023Article
- Age-related changes in layer II immature neurons of the murine piriform cortex.Frontiers in cellular neuroscience · 2023Article
- Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis.Frontiers in molecular neuroscience · 2023Article
- Immature excitatory neurons in the amygdala come of age during puberty.Developmental cognitive neuroscience · 2022Article
- Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II.Frontiers in neuroanatomy · 2022Article
- How Widespread Are the "Young" Neurons of the Mammalian Brain?Frontiers in neuroscience · 2022Article
- Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling.International journal of molecular sciences · 2021Article
- Review
- Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions.International journal of molecular sciences · 2021Review
- Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Brain plasticity is important for translational purposes since most neurological disorders and brain aging problems remain substantially incurable. In the mammalian nervous system, neurons are mostly not renewed throughout life and cannot be replaced. In humans, the increasing life expectancy explains the increase in brain health problems, also producing heavy social and economic burden. An exception to the "static" brain is represented by stem cell niches leading to the production of new neurons. Such adult neurogenesis is dramatically reduced from fish to mammals, and in large-brained mammals with respect to rodents. Some examples of neurogenesis occurring outside the neurogenic niches have been reported, yet these new neurons actually do not integrate in the mature nervous tissue. Non-newly generated, "immature" neurons (nng-INs) are also present: Prenatally generated cells continuing to express molecules of immaturity (mostly shared with the newly born neurons). Of interest, nng-INs seem to show an inverse phylogenetic trend across mammals, being abundant in higher-order brain regions not served by neurogenesis and providing structural plasticity in rather stable areas. Both newly generated and nng-INs represent a potential reservoir of young cells (a "brain reserve") that might be exploited for preventing the damage of aging and/or delay the onset/reduce the impact of neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.