Evidence map›Paper›PMID 31096579›Full record

ArticleInternational journal of molecular sciences2019

In Silico Study of the Resistance to Organophosphorus Pesticides Associated with Point Mutations in Acetylcholinesterase of Lepidoptera:

Francisco Reyes-Espinosa, Domingo Méndez-Álvarez, Miguel A Pérez-Rodríguez, Verónica Herrera-Mayorga, Alfredo Juárez-Saldivar, María A Cruz-Hernández, Gildardo Rivera

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Francisco Reyes-EspinosaLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico. frelibi@hotmail.com.ORCID 0000-0003-0727-8251
Domingo Méndez-ÁlvarezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico. doomadv@hotmail.com.
Miguel A Pérez-RodríguezDepartamento de Botánica, Universidad Autónoma Agraria Antonio Narro, Saltillo 25315, Mexico. miguel_cbg@hotmail.com.
Verónica Herrera-MayorgaLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico. veronica_qfb@hotmail.com.
Alfredo Juárez-SaldivarLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico. ajuarezs1500@gmail.com.ORCID 0000-0002-4059-7361
María A Cruz-HernándezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico. tonitacruz@gmail.com.ORCID 0000-0001-8680-6467
Gildardo RiveraLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico. gildardors@hotmail.com.ORCID 0000-0001-9842-4167
Instituto Politécnico Nacional · MXUniversidad Autónoma Agraria Antonio Narro · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An in silico analysis of the interaction between the complex-ligands of nine acetylcholinesterase (AChE) structures of Lepidopteran organisms and 43 organophosphorus (OPs) pesticides with previous resistance reports was carried out. To predict the potential resistance by structural modifications in Lepidoptera insects, due to proposed point mutations in AChE, a broad analysis was performed using computational tools, such as homology modeling and molecular docking. Two relevant findings were revealed: (1) Docking results give a configuration of the most probable spatial orientation of two interacting molecules (AChE enzyme and OP pesticide) and (2) a predicted Δ

Indexed as

AcetylcholinesteraseAnimalsComputational BiologyComputer SimulationInsecticide ResistanceLepidopteraMolecular Docking SimulationOrganophosphorus CompoundsOrganothiophosphorus CompoundsPeptide FragmentsPesticidesPhosphoramidesPoint MutationSequence AlignmentStructural Homology, ProteinacephateAcetylcholinesteraseAchE peptideOrganophosphorus CompoundsOrganothiophosphorus CompoundsPeptide FragmentsPesticidesPhosphoramidesacetylcholinesteraseinsectslepidopterousmolecular modelingorganophosphoruspesticidesresistance

Identifiers

PMID31096579
PMCPMC6566587
OpenAlexW2945951874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.