Evidence map›Paper›PMID 31096545›Full record

ArticleInternational journal of molecular sciences2019

Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia.

Minerva Mata-Rocha, Angelica Rangel-López, Elva Jiménez-Hernández, Blanca Angélica Morales-Castillo, Carolina González-Torres, Javier Gaytan-Cervantes, Enrique Álvarez-Olmos, Juan Carlos Núñez-Enríquez, Arturo Fajardo-Gutiérrez, Jorge Alfonso Martín-Trejo and 24 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Preleukemic Fusion Genes Induced via Ionizing Radiation.International journal of molecular sciences · 2023
    Review
  6. Case Report: RareGenes · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 7 institutions in 1 country.

Minerva Mata-RochaCONACyT-Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico. mmata@conacyt.mx.ORCID 0000-0003-0949-461X
Angelica Rangel-LópezCoordinacion de Investigacion en Salud, Unidad Habilitada de Apoyo al Predictamen, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico. angelica.rangell@imss.gob.mx.ORCID 0000-0001-7040-9379
Elva Jiménez-HernándezServicio de Hematologia Pediatrica, Hospital General "Gaudencio González Garza", Centro Medico Nacional (CMN) "La Raza", IMSS, 02990 Mexico City, Mexico. elvajimenez@yahoo.com.
Blanca Angélica Morales-CastilloUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. anne_tilo_kurt@hotmail.com.
Carolina González-TorresLaboratorio de Secuenciación, Division de Desarrollo de la Investigacion, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. gonzaleztorrescaro@gmail.com.
Javier Gaytan-CervantesLaboratorio de Secuenciación, Division de Desarrollo de la Investigacion, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. javier_gc50@hotmail.com.
Enrique Álvarez-OlmosUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. enrique20_85@hotmail.com.
Juan Carlos Núñez-EnríquezUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. jcarlos_nu@hotmail.com.ORCID 0000-0002-8070-9727
Arturo Fajardo-GutiérrezUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. afajardo@unam.mx.
Jorge Alfonso Martín-TrejoServicio de Hematologia, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. jorge.martin.trejo@gmail.com.
Karina Anastacia Solís-LabastidaServicio de Hematologia, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. kas_anastacia@yahoo.com.
Aurora Medina-SansónServicio de Oncología, Hospital Infantil de Mexico Federico Gómez, Secretaria de Salud, 06720 Mexico City, Mexico. auroramedina@aol.com.mx.
Janet Flores-LujanoUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. janetflores22@yahoo.com.mx.
Omar Alejandro Sepúlveda-RoblesCONACyT-Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico. sero__82@hotmail.com.ORCID 0000-0003-2152-3954
José Gabriel Peñaloza-GonzálezServicio de Onco-Pediatria, Hospital Juarez de Mexico, Secretaria de Salud, 07760 Mexico City, Mexico. penaloza_6@yahoo.es.
Laura Eugenia Espinoza-HernándezServicio de Hematologia Pediatrica, Hospital General "Gaudencio González Garza", Centro Medico Nacional (CMN) "La Raza", IMSS, 02990 Mexico City, Mexico. laura.espinosah@imss.gob.mx.
Nora Nancy Núñez-VillegasServicio de Hematologia Pediatrica, Hospital General "Gaudencio González Garza", Centro Medico Nacional (CMN) "La Raza", IMSS, 02990 Mexico City, Mexico. nanuvi_2401@yahoo.com.mx.
Rosa Martha Espinosa-ElizondoServicio de Hematologia Pediatrica, Hospital General de Mexico, Secretaria de Salud, 06726 Mexico City, Mexico. rmespinosa1605@hotmail.com.
Beatriz Cortés-HerreraServicio de Hematologia Pediatrica, Hospital General de Mexico, Secretaria de Salud, 06726 Mexico City, Mexico. beatrizcortes101087@gmail.com.
José Refugio Torres-NavaServicio de Oncología, Hospital Pediatrico de Moctezuma, Secretaria de Salud de la Ciudad de Mexico, Ciudad de Mexico, 15530 Mexico City, Mexico. torresoncoped@live.com.mx.
Luz Victoria Flores-VillegasServicio de Hematologia Pediatrica, Centro Medico Nacional "20 de Noviembre", ISSSTE, 03229 Mexico City, Mexico. victoriabanco@yahoo.com.mx.
Laura Elizabeth Merino-PasayeServicio de Hematologia Pediatrica, Centro Medico Nacional "20 de Noviembre", ISSSTE, 03229 Mexico City, Mexico. sketch0712@gmail.com.
Vilma Carolina Bekker-MéndezUnidad de Investigacion Medico en Inmunologia e Infectologia, Hospital de Infectologia "Dr. Daniel Méndez Hernández", "La Raza", IMSS, 02990 Mexico City, Mexico. bekkermendez@yahoo.com.
Martha Margarita Velázquez-AviñaServicio de Onco-Pediatria, Hospital Juarez de Mexico, Secretaria de Salud, 07760 Mexico City, Mexico. m_mvelazquez@yahoo.com.mx.
María Luisa Pérez-SaldívarUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. maria_luisa_2000_mx@yahoo.com.
Benito Alejandro Bautista-MartínezServicio de Hematologia, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. aufgefuhrt@hotmail.com.
Raquel Amador-SánchezServicio de Hematologia Pediatrica, Hospital General Regional "Carlos McGregor Sanchez Navarro", IMSS, 03100 Mexico City, Mexico. dibs_amador@hotmail.com.
Ana Itamar González-AvilaServicio de Hematologia Pediatrica, Hospital General Regional "Carlos McGregor Sanchez Navarro", IMSS, 03100 Mexico City, Mexico. itamarga@hotmail.com.
Silvia Jiménez-MoralesLaboratorio de Genomica del Cancer del Instituto Nacional de Medicina Genomica (INMEGEN), 14610 Mexico City, Mexico. sjimenez@inmegen.gob.mx.ORCID 0000-0002-6590-9712
David Aldebarán Duarte-RodríguezUnidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. turunci@gmail.com.
Jessica Denisse Santillán-JuárezServicio de Hemato-Oncologia Pediatrica, Hospital Regional 1° de Octubre, ISSSTE, 07300 Mexico City, Mexico. jessydenise22@hotmail.com.
Alejandra Jimena García-VelázquezServicio de Hemato-Oncologia Pediatrica, Hospital Regional 1° de Octubre, ISSSTE, 07300 Mexico City, Mexico. ale.garciavelazquez@gmail.com.
Haydeé Rosas-VargasUnidad de Investigacion Medica en Genética Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico. hayrov@gmail.com.
Juan Manuel Mejía-AranguréCoordinación de Investigacion en Salud, IMSS, Torre Academia Nacional de Medicina, 06720 Mexico City, Mexico. juan.mejiaa@imss.gob.mx.
Centro Medico Nacional Siglo XXI · MXInstitute for Social Security and Services for State Workers · MXSecretaria de Salud · MXCentro Médico Nacional La Raza · MXHospital General de México · MXMexican Social Security Institute · MXNational Institute of Genomic Medicine · MX

Funding

Consejo Nacional de Ciencia y Tecnología CB-2015-1-258042, FIS/IMSS/PROT/1548Consejo Nacional de Ciencia y Tecnología FONCICYT/37/2018, FIS/IMSS/PROT1782Consejo Nacional de Ciencia y Tecnología PDCPN2013-01-215726, FIS/IMSS/PROT/1364Consejo Nacional de Ciencia y Tecnología SALUD-2010-1-141026, FIS/IMSS/PROT/895Consejo Nacional de Ciencia y Tecnología SALUD 2015-1-262190, FIS/IMSS/PROT/1533Instituto Mexicano del Seguro Social FIS/IMSS/PROT/G12/1134Instituto Mexicano del Seguro Social FIS/IMSS/PROT/G15/1477Instituto Mexicano del Seguro Social FIS/IMSS/PROT/MD13/1254Instituto Mexicano del Seguro Social , FIS/IMSS/PROT/MD15/1504Instituto Mexicano del Seguro Social FIS/IMSS/PROT/PRIO/11/017Instituto Mexicano del Seguro Social FIS/IMSS/PROT/PRIO/14/031Instituto Mexicano del Seguro Social FIS/IMSS/PROT/PRIO/15/048
6 · The paper itself

Abstract

Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified:

Indexed as

AdolescentAdultChildChild, PreschoolCREB-Binding ProteinDyneinsETS Translocation Variant 6 ProteinFemaleGene Expression Regulation, NeoplasticGene RearrangementGTPase-Activating ProteinsHumansIkaros Transcription FactorInfantMaleMexicoCREB-Binding ProteinCREBBP protein, humanDNAH14 protein, humanDyneinsETS Translocation Variant 6 ProteinGTPase-Activating ProteinsIkaros Transcription FactorIKZF1 protein, humanNuclear ProteinsNUFIP1 protein, humanOncogene Proteins, FusionProto-Oncogene Proteins c-etsReceptors, Cytoplasmic and NuclearRepressor ProteinsRNA-Binding ProteinsRNA Cap-Binding ProteinsSNUPN protein, humanSRGAP3 protein, humanchromosomal translocationfusion genegenetic variationsleukemogenesisrisk stratificationRNA sequencing

Identifiers

PMID31096545
PMCPMC6566803
OpenAlexW2945681080

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.