Trial reportHormone research in paediatrics2019
The Incidence of Childhood Thyrotoxicosis Is Increasing in Both Girls and Boys in Sweden.
Trial report in Hormone research in paediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- 2022 European Thyroid Association Guideline for the management of pediatric Graves' disease.European thyroid journal · 2022Guideline
- An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- Clinical Pattern of Graves' Disease and Management Preferences Among Pediatric Endocrinologists in Saudi Arabia, A Decade of Experience.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- From Functional Disorder to a Life-Threatening Emergency: A Rare Adolescent Case of Thyrotoxicosis.Cureus · 2026Article
- Overall, sex-and race/ethnicity-specific prevalence of thyroid dysfunction in US adolescents aged 12-18 years.Frontiers in public health · 2024Article
- Different doses of methimazole treatment of children and adolescents with graves' disease: a clinical study based on 161 cases of outpatients.BMC endocrine disorders · 2023Article
- Graves' disease: moving forwards.Archives of disease in childhood · 2023Review
- Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease.Frontiers in medicine · 2023Article
- Hyperthyroidism in children and adolescents: Experience in a university hospital in ColombiaBiomedica : revista del Instituto Nacional de Salud · 2022Article
- [Definitive treatment of Graves' disease in children].Problemy endokrinologii · 2022Article
- Hyperthyroidism in adolescents.Endocrine connections · 2021Review
- How to use thionamide anti-thyroid drug in the young- what's new?Thyroid research · 2021Review
- An Estimation of the Incidence of Thyroiditis Among Girls in Primary Care in SpainJournal of clinical research in pediatric endocrinology · 2021Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe found an increase in the incidence rate (IR) of childhood thyrotoxicosis (CT) during the 1990s in central Sweden. The optimal treatment method for CT is a subject that is still debated upon.
objectivesTo investigate whether the increase in IR of CT in Sweden persists and to study the treatment outcome.
methodChildren <16 years of age diagnosed with CT during 2000-2009 and living in 1 of 5 counties in central Sweden were identified retrospectively using hospital registers. Data on clinical and biochemical characteristics and outcomes of treatment were collected from medical records. The corresponding data from 1990 to 1999 were pooled with the new data.
resultsIn total, 113 children were diagnosed with CT during 1990-2009 in the study area. The overall IR was 2.2/100,000 person-years (95% CI 1.2-2.5/100,000 person-years). The IR was significantly higher during 2000-2009 than during 1990-1999 (2.8/100,000 [2.2-3.6] vs. 1.6/100,000 person-years [1.2-2.2], p = 0.006). The increase was significant for both sexes. Seventy percent of the patients who completed the planned initial treatment with antithyroid drugs (ATDs) and were not lost to follow-up relapsed within 3 years. Boys tended to relapse earlier than girls (6.0 months after drug withdrawal [95% CI 1.9-10.0] vs. 12.0 months [95% CI 6.8-17.3], p = 0.074).
conclusionsThe IR of CT is increasing in both girls and boys. Relapse rate after withdrawal of ATD treatment is 70%. Boys tend to relapse earlier than girls, and this needs to be further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.