Evidence map›Paper›PMID 31096124›Full record

ReviewCurrent opinion in virology2019

Interactions between noroviruses, the host, and the microbiota.

Forrest C Walker, Megan T Baldridge

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  4. Article
  5. Article
  6. Cultivation of gut microorganisms of the marine ascidianMarine life science & technology · 2022
    Article
  7. Knowledge, Awareness, and Prevention of Norovirus Infection among Kindergarten Parents in Chengdu, China.International journal of environmental research and public health · 2022
    Article
  8. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
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  15. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Forrest C WalkerDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Megan T BaldridgeDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mbaldridge@wustl.edu.
Washington University in St. Louis · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
Role of CD300 Family in Norovirus Tropism, Persistence, and ImmunityR01AI127552 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T, FREMONT, DAVED H. · 2017 to 2021
$3.5M
Suppression of Enteric Norovirus Infection by Microbiota-Regulated Bile AcidsR01AI141478 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2019 to 2023
$2.7M
Norovirus regulation via bacterial modulation of interferon-lambdaR01AI139314 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.0M
NIAID NIH HHS R01 AI127552NIAID NIH HHS R01 AI139314NIAID NIH HHS R01 AI141478NIDDK NIH HHS P30 DK052574NIGMS NIH HHS T32 GM007067NIGMS NIH HHS T32 GM139774
6 · The paper itself

Abstract

In recent years, appreciation has been growing for the role that the microbiota plays in interactions between the host and various pathogens, including norovirus. Proviral and antiviral effects of the microbiota have been observed for both human and murine noroviruses, and it has become clear that direct effects of microbes and their metabolites as well as indirect effects of commensals on the host are key in modulating pathogenesis. In particular, a common thread has emerged in the ability of members of the microbiota to regulate the host interferon response, thereby modulating norovirus infection. Here, we highlight key differences between human and murine noroviruses and their interactions with the microbiota, while also underscoring shared characteristics between noroviruses and other gastrointestinal viruses.

Indexed as

Gastrointestinal MicrobiomeNorovirusAnimalsCaliciviridae InfectionsFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGastroenteritisHost-Parasite InteractionsHumansInterferonsMiceMicrobial InteractionsModels, AnimalVirus ReplicationFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseInterferons

Identifiers

PMID31096124
PMCPMC6768699
OpenAlexW2945574515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.