ArticleActa biomaterialia2019
Bioprinting of stem cell expansion lattices.
Article in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Three-dimensional bioprinted in vitro glioma tumor constructs for synchrotron microbeam radiotherapy dosimetry and biological study using gelatin methacryloyl hydrogel.Scientific reports · 2025Article
- Dissecting the Interplay Mechanism among Process Parameters toward the Biofabrication of High-Quality Shapes in Embedded Bioprinting.Advanced functional materials · 2024Article
- Diffusion-Based 3D Bioprinting Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Aqueous Two-Phase Enabled Low Viscosity 3D (LoV3D) Bioprinting of Living Matter.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Bioprinted Membranes for Corneal Tissue Engineering: A Review.Pharmaceutics · 2022Review
- Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation.Frontiers in bioengineering and biotechnology · 2022Review
- Pectin-based bioinks for 3D models of neural tissue produced by a pH-controlled kinetics.Frontiers in bioengineering and biotechnology · 2022Article
- 3D Bioprinting of Cell-Laden Hydrogels for Improved Biological Functionality.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Advancing models of neural development with biomaterials.Nature reviews. Neuroscience · 2021Review
- Adaptable hydrogel with reversible linkages for regenerative medicine: Dynamic mechanical microenvironment for cells.Bioactive materials · 2021Review
- Emergence of FRESH 3D printing as a platform for advanced tissue biofabrication.APL bioengineering · 2021Article
- 3D Bioprinting using UNIversal Orthogonal Network (UNION) Bioinks.Advanced functional materials · 2021Article
- Digitally Fabricated and Naturally Augmented In Vitro Tissues.Advanced healthcare materials · 2021Review
- Prospects and Challenges of Translational Corneal Bioprinting.Bioengineering (Basel, Switzerland) · 2020Review
- Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication.Scientific reports · 2020Article
- Bioprinting Cell- and Spheroid-Laden Protein-Engineered Hydrogels as Tissue-on-Chip Platforms.Frontiers in bioengineering and biotechnology · 2020Article
- Biomaterials Based on Marine Resources for 3D Bioprinting Applications.Marine drugs · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Stem cells have great potential in regenerative medicine, with neural progenitor cells (NPCs) being developed as a therapy for many central nervous system diseases and injuries. However, one limitation to the clinical translation of stem cells is the resource-intensive, two-dimensional culture protocols required for biomanufacturing a clinically-relevant number of cells. This challenge can be overcome in an easy-to-produce and cost-effective 3D platform by bioprinting NPCs in a layered lattice structure. Here we demonstrate that alginate biopolymers are an ideal bioink for expansion lattices and do not require chemical modifications for effective NPC expansion. Alginate bioinks that are lightly crosslinked prior to printing can shield printed NPCs from potential mechanical damage caused by printing. NPCs within alginate expansion lattices remain in a stem-like state while undergoing a 2.5-fold expansion. Importantly, we demonstrate the ability to efficiently remove NPCs from printed lattices for future down-stream use as a cell-based therapy. These results demonstrate that 3D bioprinting of alginate expansion lattices is a viable and economical platform for NPC expansion that could be translated to clinical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.