Evidence map›Paper›PMID 31095958›Full record

ArticleJournal of pharmaceutical sciences2019

Enhancing Tumor Drug Distribution With Ultrasound-Triggered Nanobubbles.

Pinunta Nittayacharn, Hai-Xia Yuan, Christopher Hernandez, Peter Bielecki, Haoyan Zhou, Agata A Exner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 77 citations in OpenAlex.

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  10. Nanoparticles in Medicine: Current Status in Cancer Treatment.International journal of molecular sciences · 2023
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  16. The Influence of Nanobubble Size and Stability on Ultrasound Enhanced Drug Delivery.Langmuir : the ACS journal of surfaces and colloids · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Pinunta NittayacharnDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106.
Hai-Xia YuanDepartment of Ultrasound, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai 200032, China; Department of Radiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106.
Christopher HernandezDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106.
Peter BieleckiDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106.
Haoyan ZhouGSK 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426-0989.
Agata A ExnerDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106; Department of Radiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106. Electronic address: agata.exner@case.edu.
Case Western Reserve University · USZhongshan Hospital · CN

Funding

Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMAR01EB025741 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI James Peter Basilion, Agata A Exner · 2018 to 2026
$4.1M
Pressure-Driven Local Drug Delivery System for Treatment of Liver CancerR01EB016960 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI EXNER, AGATA A · 2013 to 2017
$1.8M
Injectable Implants for Increased Tumor Treatment Volume Using Pressure Driven DiffusionF31CA200373 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HERNANDEZ, CHRISTOPHER · 2015 to 2016
$66k
NCI NIH HHS F31 CA200373NIBIB NIH HHS R01 EB016960NIBIB NIH HHS R01 EB025741
6 · The paper itself

Abstract

Issues with limited intratumoral drug penetration and heterogeneous drug distribution continue to impede the therapeutic efficacy of nanomedicine-based delivery systems. Ultrasound (US)-enhanced drug delivery has emerged as one effective means of overcoming these challenges. Acoustic cavitation in the presence of nanoparticles has shown to increase the cellular uptake and distribution of chemotherapeutic agents in vivo. In this study, we investigated the potential of a drug-loaded echogenic nanoscale bubbles in combination with low frequency (3 MHz), high energy (2 W/cm

Indexed as

MicrobubblesAnimalsAntineoplastic AgentsCell Line, TumorColorectal NeoplasmsCombined Modality TherapyDoxorubicinDrug CarriersHumansMiceNanoparticlesParticle SizePolymersTissue DistributionUltrasonic TherapyXenograft Model Antitumor AssaysAntineoplastic AgentsDoxorubicinDrug CarriersPolymerscavitationdoxorubicindrug deliverynanobubblessonoporationultrasound

Identifiers

PMID31095958
PMCPMC6708467
OpenAlexW2946666505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.