ArticleAmerican journal of ophthalmology2019
OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness, and Minimum Cross-Sectional Area in Healthy Eyes.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Optic nerve head abnormalities in primary open-angle glaucoma and their associations with axial length.Japanese journal of ophthalmology · 2026Article
- Diagnostic Role of Multimodal Imaging in Optic Disc Diseases.Diagnostics (Basel, Switzerland) · 2026Review
- Intrapapillary Damage and Its Functional Association in Normal Tension Glaucomatous Eyes With and Without Peripapillary Intrachoroidal Cavitation.Investigative ophthalmology & visual science · 2026Observational
- Structural and Functional Progression in Open-Angle Glaucoma with Unilateral Peripapillary Intrachoroidal Cavitation.Journal of clinical medicine · 2026Article
- Comparison of Deep Optic Nerve Head Structures and Optic Disc Morphology in Unilateral Peripapillary Intrachoroidal Cavitation.Ophthalmology science · 2026Article
- High Myopia-Induced Optic Nerve Head Deformation and Glaucoma Progression: A Three-Year Follow-Up Study.Investigative ophthalmology & visual science · 2025Article
- OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.American journal of ophthalmology · 2024Article
- Association between eyeball asymmetry and offset of openings in optic nerve head canal assessed by posterior polar eyeball topography.Scientific reports · 2024Article
- Optical Coherence Tomographic Optic Nerve Head Morphology in Myopia III: The Exposed Neural Canal Region in Healthy Eyes-Implications for High Myopia.American journal of ophthalmology · 2024Article
- Deep Optic Nerve Head Morphology in Tilted Disc Syndrome and Its Clinical Implication on Visual Damage.Investigative ophthalmology & visual science · 2023Article
- OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.American journal of ophthalmology · 2023Article
- Deep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length.American journal of ophthalmology · 2023Observational
- Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia.Investigative ophthalmology & visual science · 2023Article
- Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma.Investigative ophthalmology & visual science · 2022Article
- 3D Reconstruction of a Unitary Posterior Eye by Converging Optically Corrected Optical Coherence and Magnetic Resonance Tomography Images via 3D CAD.Translational vision science & technology · 2022Article
- OCT detected optic nerve head remodeling in a young adult with early progressive myopia.American journal of ophthalmology case reports · 2022Article
- Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography.American journal of ophthalmology · 2022Article
- Offset of openings in optic nerve head canal at level of Bruch's membrane, anterior sclera, and lamina cribrosa.Scientific reports · 2021Article
- Elongation of the disc-fovea distance and retinal vessel straightening in high myopia in a 10-year follow-up of the Beijing eye study.Scientific reports · 2021Article
- Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
purposeTo assess anterior scleral canal opening (ASCO) offset relative to Bruch's membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes.
designCross-sectional study.
methodsAfter optical coherence tomography optic nerve head and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented. Planes, centroids, size, and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural canal axis and the BMO plane perpendicular vector. NCMCA was defined by projecting BMO and ASCO points onto a neural canal axis perpendicular plane and measuring the area of overlap. The angular distance between superior and inferior peak RNFLT was measured, and correlations between RFNLT, BMO, ASCO, ASCO/BMO offset, and NCMCA were assessed.
resultsMean (SD) NCMCA was significantly smaller than either the BMO or ASCO area (1.33 (0.42), 1.82 (0.38), 2.22 (0.43) mm
conclusionsASCO/BMO offset underlies neural canal direction, obliqueness, and NCMCA. RNFLT is more strongly correlated to NCMCA than to BMO or ASCO, and its peripapillary distribution is influenced by neural canal direction.
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Registered trials
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