Trial reportPloS one2019
Development and validation of the Korean version of the medication regimen complexity index.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Effect of Pharmacist-Led Intervention in Elderly Patients through a Comprehensive Medication Reconciliation: A Randomized Clinical Trial.Yonsei medical journal · 2023Trial
- Association between medication regimen complexity and glycemic control among patients with type 2 diabetes.Journal of the American Pharmacists Association : JAPhATrial
- Association of potentially inappropriate prescribing with drug-drug interactions and medication regimen complexity in geriatric patients: a cross-sectional analytical study.BMC geriatrics · 2026Observational
- Medication Regimen Complexity and Patient-Reported Adverse Drug Events in Korean Community Pharmacies: A Cross-Sectional Study.Pharmacy (Basel, Switzerland) · 2026Article
- Risk Prediction of Major Adverse Cardiovascular Events Within One Year After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome: Machine Learning-Based Time-to-Event Analysis.JMIR medical informatics · 2025Observational
- Identification and evaluation of drug-related problems in community pharmacy in Turkey: a descriptive prevalence study.BMC primary care · 2025Article
- Association of medication regimen complexity index with ADRs in HIV/AIDS patients: a retrospective cohort study.Frontiers in pharmacology · 2025Article
- Complexity of the Therapeutic Regimen in Older Adults with Cancer: Associated Factors.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Effect of Multi-Dose Dispensing on Medication Regimen Complexity: A Real-World Study.Journal of clinical medicine · 2024Article
- A Study on Types of Medication Adherence in Hypertension among Older Patients and Influencing Factors.Healthcare (Basel, Switzerland) · 2022Article
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
- Development of medication regimen complexity index: Japanese version and application in elderly patients.International journal of clinical pharmacy · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The medication regimen complexity index (MRCI), originally developed in English, is a reliable and valid tool to assess the complexity of pharmacotherapy. This study aimed to validate the Korean version of MRCI (MRCI-K). A cross-cultural methodological study comprising 335 discharged patients of a tertiary hospital in Korea was conducted. The translation process included translation into Korean by two clinical pharmacists, back translation by two native speakers, and a pretest of the tool, culminating in the Korean version of MRCI-K. Reliability analysis was assessed using inter-rater and test-retest reliability with 25 randomly selected patients. Convergent and discriminant validity analyses were conducted by correlating MRCI scores with medication number, age, sex, adverse drug reaction (ADR) reports, and length of stay. The criterion validity was confirmed through evaluation by a nine-member expert panel that subjectively ranked these regimens. The reliability analysis demonstrated excellent internal consistency (Cronbach's α = 0.977), and the intraclass correlation coefficient exceeded 0.90 for all cases. The correlation coefficient for the number of medications was 0.955 (P < 0.001). Weak significant correlations were observed with age and length of stay. The MRCI-K group with ADR reports scored higher (mean, 31.8) than the group without ADR reports (mean, 27.3). The expert panel's ranking had a stronger correlation with the MRCI ranking than the medication number ranking. MRCI-K has similar reliability and validity as MRCI and is useful for analyzing therapeutic regimens with potential applications in both practice and research in Korea.
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