ArticlePloS one2019
Retrospective analysis of diabetic foot osteomyelitis management and outcome at a tertiary care hospital in the UK.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rationales for Antibiotic Treatment Versus Direct Surgical Resection in Various Strata of Diabetic Foot Osteomyelitis-Literature Review and Expert Opinions.Antibiotics (Basel, Switzerland) · 2026Article
- Analysis of Biomarkers in Diabetic Foot Ulcer Patients With Dampness-Heat Syndrome Based on 4D-DIA Proteomics Technology.Journal of diabetes research · 2026Article
- Panoramic description of ROS-based nanotechnology for osteomyelitis therapy: Challenges, opportunities, and prospects.Theranostics · 2026Review
- Osteomyelitis and Its Main Determinants in Patients With Diabetic Foot Ulcer: A Cross-Sectional Study.Health science reports · 2025Article
- Article
- Outcome of diabetic foot ulcers at a Tertiary Care Foot Centre in Pakistan.International wound journal · 2025Article
- Microbiological characterization of neuropathic diabetic foot infection: a retrospective study at a Portuguese tertiary hospital.BMC infectious diseases · 2024Article
- Commentary: Development of a resource-use measure to capture costs of diabetic foot ulcers to the United Kingdom National Health Service, patients and society.Journal of research in nursing : JRN · 2023Article
- Successful Outpatient Treatment of Severe Diabetic-Foot Myositis and Osteomyelitis Caused by Extensively Drug-Resistant Enterococcus faecalis with Teicoplanin plus Rifampicin: A Case Report.The American journal of case reports · 2023Article
- The association between bacteria and outcome and the influence of sampling method, in people with a diabetic foot infection.Infection · 2023Article
- Isolation and Characterization of Bacteriophages Active againstArchives of Razi Institute · 2022Article
- Microbial Profile and Antibiotic Susceptibility Pattern in Diabetic Patients with Mild, Moderate, and Severe Foot Infections in Tehran.Archives of Razi Institute · 2022Article
- Skeletal infections: microbial pathogenesis, immunity and clinical management.Nature reviews. Microbiology · 2022Review
- The effectiveness of systemic antibiotics for osteomyelitis of the foot in adults with diabetes mellitus: a systematic review protocol.Journal of foot and ankle research · 2022Article
- Synthesis and Biological Evaluation of Novel Cinnamic Acid-Based Antimicrobials.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Treating Diabetic Foot Osteomyelitis: A Practical State-of-the-Art Update.Medicina (Kaunas, Lithuania) · 2021Review
- Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.Pathogens (Basel, Switzerland) · 2021Review
- Article
- Adjunctive Rifampin Therapy For Diabetic Foot Osteomyelitis in the Veterans Health Administration.JAMA network open · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to analyse retrospectively management and outcomes of the diabetic foot osteomyelitis (DFOM) multi-disciplinary team at St Thomas' Hospital, London.
methodsPatients admitted during 2015 with diagnosis of DFOM were included. Data were obtained from medical and microbiology records.
results275 patients were admitted for DF infection in 2015: 45.1% had OM (75% males). 40% were newly diagnosed with DF ulcer (DFU). 81% patients had X-ray and 28% had MRI. Bone infection was confirmed by MC&S in 53% cases. 930 microbiological isolates were obtained: 63% were Gram-positive microorganisms [S.aureus and MRSA (~40%), CoNS (20%), and E.faecalis (8%)]. All MRSA were vancomycin and linezolid sensitive. 23.2% isolates were vancomycin-resistant enterococci. 24% isolates were Gram-negative organisms: P.aeruginosa (42%), E.coli (13%), and E.cloacae (12%). Meropenem resistance was low; 5.4% P.aeruginosa, 87.5% A.baumanii. 76% patients received co-amoxiclav; 41% received ≥3 antibiotics; 17% received >3 months antibiotics. Hospital mean-length of stay was 26.1 days. Ulcer time-to-heal was >6 months in 25% patients. 22% ulcers healed without surgery, 60% healed after minor amputation, 12% patients had major amputation.
conclusionDespite current MDT approach, many patients progress to amputation. DF-OM still represents a challenging clinical condition, requiring further study to develop better management guidelines.
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