ArticlePLoS biology2019
Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Quantifying antibiotic susceptibility and inoculum effects using transient dynamics of Pseudomonas aeruginosa.PLoS computational biology · 2026Article
- Co-occurrence of blaBMC microbiology · 2026Article
- Exploring factors contributing to antibiotic resistance: A cross-sectional empirical study in Bangladesh.PloS one · 2026Article
- Improving policy design and epidemic response using integrated models of economic choice and disease dynamics with behavioral feedback.PLoS computational biology · 2025Article
- Therapeutic Drug Monitoring of Amikacin and Colistin in Patients with Multidrug-Resistant Gram-Negative Infections Using a Portable Plasmonic Biosensor.Analytical chemistry · 2025Article
- Microbial Primer: Challenges and opportunities in the treatment of chronic polymicrobial infections ‒ an eco-evolutionary perspective.Microbiology (Reading, England) · 2025Review
- Overcoming challenges in the economic evaluation of interventions to optimise antibiotic use.Communications medicine · 2024Review
- Review
- Advantage of precision metagenomics for urinary tract infection diagnostics.Frontiers in cellular and infection microbiology · 2023Article
- Hygiene may attenuate selection for antibiotic resistance by changing microbial community structure.Evolution, medicine, and public health · 2023Article
- Reflections on Drivers for the Emergence and Spread of Antimicrobial Resistant Bacteria Detected from Chickens reared on Commercial Layer Farms in Mukono District, Uganda.Veterinary medicine (Auckland, N.Z.) · 2023Article
- Methicillin ResistantInfection and drug resistance · 2023Review
- Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome Model.mSphere · 2022Article
- Evolving antibiotic spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Comparing optimization criteria in antibiotic allocation protocols.Royal Society open science · 2022Article
- Burden of Antimicrobial Resistance: Compared to What?Epidemiologic reviews · 2022Article
- Rapid Detection of Bacterial Pathogens and Antimicrobial Resistance Genes in Clinical Urine Samples With Urinary Tract Infection by Metagenomic Nanopore Sequencing.Frontiers in microbiology · 2022Article
- Adapting environmental surveillance for polio to the need to track antimicrobial resistance.Bulletin of the World Health Organization · 2021Article
- Rapid Methods for Antimicrobial Resistance Diagnostics.Antibiotics (Basel, Switzerland) · 2021Review
- Drivers of Antibiotic Resistance Transmissionin Low- and Middle-Income Countriesfrom a "One Health" Perspective-A Review.Antibiotics (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Rapid point-of-care resistance diagnostics (POC-RD) are a key tool in the fight against antibiotic resistance. By tailoring drug choice to infection genotype, doctors can improve treatment efficacy while limiting costs of inappropriate antibiotic prescription. Here, we combine epidemiological theory and data to assess the potential of resistance diagnostics (RD) innovations in a public health context, as a means to limit or even reverse selection for antibiotic resistance. POC-RD can be used to impose a nonbiological fitness cost on resistant strains by enabling diagnostic-informed treatment and targeted interventions that reduce resistant strains' opportunities for transmission. We assess this diagnostic-imposed fitness cost in the context of a spectrum of bacterial population biologies and find that POC-RD have a greater potential against obligate pathogens than opportunistic pathogens already subject to selection under "bystander" antibiotic exposure during asymptomatic carriage (e.g., the pneumococcus). We close by generalizing the notion of RD-informed strategies to incorporate carriage surveillance information and illustrate that coupling transmission-control interventions to the discovery of resistant strains in carriage can potentially select against resistance in a broad range of opportunistic pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.