Evidence map›Paper›PMID 31095446›Full record

ArticleRadiation research2019

Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats.

Marek Lenarczyk, Amy Kronenberg, Marylou Mäder, Paula E North, Richard Komorowski, Qunli Cheng, Mark P Little, I-Hung Chiang, Chiara LaTessa, James Jardine and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Marek Lenarczyka Division of Congenital Cardiac Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Amy Kronenberge Lawrence Berkeley National Laboratory, Berkeley, California.
Marylou Mäderb Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Paula E Northc Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Richard Komorowskic Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Qunli Chenga Division of Congenital Cardiac Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Mark P Littlef Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.
I-Hung Chiangg Collider-Accelerator Department.
Chiara LaTessag Collider-Accelerator Department.
James Jardineh Biology Department, Brookhaven National Laboratory, Upton, New York.
John E Bakera Division of Congenital Cardiac Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Adult Congenital Heart Association · USCereal Disease Laboratory · USBrookhaven National Laboratory · USLawrence Berkeley National Laboratory · USNational Cancer Institute · USRadiation Oncology Associates · US

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Radiotherapy with sparsely ionizing photons is a cornerstone of successful cancer treatment. Age at time of exposure to radiation is known to influence biological outcomes for many end points. The effect of dose and age at exposure upon the occurrence of radiogenic cardiovascular disease is poorly understood. The goal of this work was to determine the response of maleWAG/RijCmcr rats at 6 months of age to gamma rays, and at 6 months or 6 weeks of age to X rays, using clinically relevant biomarkers of cardiovascular disease and kidney injury. Overall, there were significant radiation-induced effects on the levels of bicarbonate (

Indexed as

Age FactorsAnimalsDose-Response Relationship, RadiationGamma RaysHeart DiseasesKidney DiseasesMaleRadiation Injuries, ExperimentalRatsRats, WistarRisk Factors

Identifiers

PMID31095446
PMCPMC10654917
OpenAlexW2944975296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.