Evidence map›Paper›PMID 31095372›Full record

ArticleBioconjugate chemistry2020

Multimodal Positron Emission Tomography Imaging to Quantify Uptake of

Mark E Lobatto, Tina Binderup, Philip M Robson, Luuk F P Giesen, Claudia Calcagno, Julia Witjes, Francois Fay, Samantha Baxter, Chang Ho Wessel, Mootaz Eldib and 10 more

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Nanomedicine for Diagnosis and Treatment of Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  6. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  7. Review
  8. Article
  9. Imaging-guided nanomedicine development.Current opinion in chemical biology · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 5 countries.

Mark E LobattoTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Tina BinderupTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Philip M RobsonTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Luuk F P GiesenTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Claudia CalcagnoTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Julia WitjesTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Francois FayTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.ORCID 0000-0001-7405-5600
Samantha BaxterTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Chang Ho WesselTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Mootaz EldibTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Jason BiniTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Sean D CarlinDepartment of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.
Erik S G StroesDepartment of Vascular Medicine , Academic Medical Center , 1105 AZ Amsterdam , The Netherlands.
Gert StormDepartment of Targeted Therapeutics, MIRA Institute , University of Twente , 7522 NB Enschede , The Netherlands.
Andreas KjaerDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging , Rigshospitalet & University of Copenhagen , 2100 Copenhagen , Denmark.
Jason S LewisDepartment of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.ORCID 0000-0001-7065-4534
Thomas ReinerDepartment of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.ORCID 0000-0002-7819-5480
Zahi A FayadTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Willem J M MulderTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.ORCID 0000-0001-8665-3878
Carlos Pérez-MedinaTranslational and Molecular Imaging Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.ORCID 0000-0002-6011-0629
Icahn School of Medicine at Mount Sinai · USMemorial Sloan Kettering Cancer Center · USUniversity of Copenhagen · DKAmsterdam UMC Location University of Amsterdam · NLEindhoven University of Technology · NLSpaarne Gasthuis · NLSpanish National Centre for Cardiovascular Research · ESUniversité Paris-Sud · FRUtrecht University · NL

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
PET/MRI to study nanotherapy in atherosclerosisR01HL125703 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM · 2015 to 2018
$2.4M
Anti-inflammatory nanoparticle formulations to treat atherosclerosisR01HL118440 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM, NAHRENDORF, MATTHIAS · 2014 to 2017
$2.3M
NCI NIH HHS P30 CA008748NHLBI NIH HHS HHSN268201000045CNHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL118440NHLBI NIH HHS R01 HL125703NIBIB NIH HHS R01 EB009638
6 · The paper itself

Abstract

Nanotherapy has recently emerged as an experimental treatment option for atherosclerosis. To fulfill its promise, robust noninvasive imaging approaches for subject selection and treatment evaluation are warranted. To that end, we present here a positron emission tomography (PET)-based method for quantification of liposomal nanoparticle uptake in the atherosclerotic vessel wall. We evaluated a modular procedure to label liposomal nanoparticles with the radioisotope zirconium-89 (

Indexed as

AnimalsAorta, AbdominalAtherosclerosisLiposomesMalePlaque, AtheroscleroticPositron-Emission TomographyRabbitsRadioisotopesTissue DistributionZirconiumLiposomesRadioisotopesZirconiumZirconium-89

Identifiers

PMID31095372
PMCPMC7460274
OpenAlexW2945983164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.