Evidence map›Paper›PMID 31094489›Full record

ArticleJournal of psychiatry & neuroscience : JPN2019

Time heals all wounds? A 2-year longitudinal diffusion tensor imaging study in major depressive disorder

Jonathan Repple, Dario Zaremba, Susanne Meinert, Dominik Grotegerd, Ronny Redlich, Katharina Förster, Katharina Dohm, Nils Opel, Tim Hahn, Verena Enneking and 11 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Jonathan ReppleFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Dario ZarembaFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Susanne MeinertFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Dominik GrotegerdFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Ronny RedlichFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Katharina FörsterFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Katharina DohmFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Nils OpelFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Tim HahnFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Verena EnnekingFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Elisabeth J. LeehrFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Joscha BöhnleinFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Fanni DzvonyarFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Lisa SindermannFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Nils WinterFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Janik GoltermannFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Harald KugelFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Jochen BauerFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Walter HeindelFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Volker AroltFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
Udo DannlowskiFrom the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).
FH Münster · DEUniversity of Münster · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cross-sectional studies have repeatedly shown impaired white matter integrity in patients with major depressive disorder. Longitudinal analyses are missing from the current research and are crucial to elucidating the impact of disease trajectories on white matter impairment in major depressive disorder. Methods: Fifty-nine patients with major depressive disorder receiving inpatient treatment, as well as 49 healthy controls, took part in a prospective study. Participants were scanned twice (baseline and follow-up), approximately 2.25 years apart, using diffusion tensor imaging. We analyzed diffusion metrics using tract-based spatial statistics. Results: At baseline, patients had higher mean diffusivity in a large bilateral frontal cluster comprising the body and genu of the corpus callosum, the anterior and superior corona radiata, and the superior longitudinal fasciculus. A significant group × time interaction revealed a decrease of mean diffusivity in patients with major depressive disorder over time, abolishing group differences at follow-up. This effect was observed irrespective of disease course in the follow-up period. Limitations: Analyzing the course of illness is challenging because of recollection biases in patients with major depressive disorder. Conclusion: This study reports follow-up diffusion tensor imaging data in patients with major depressive disorder after an acute depressive episode. We demonstrated impaired prefrontal white matter microstructure (higher mean diffusivity) at baseline in patients with major depressive disorder, which normalized at follow-up after 2 years, irrespective of disease course. This might have been due to a general treatment effect and might have reflected recovery of white matter integrity.

Indexed as

AdultBrainDiffusion Tensor ImagingFemaleHumansLongitudinal StudiesMajor Depressive DisorderMaleMiddle AgedNeural PathwaysProspective StudiesRecurrenceSeverity of Illness IndexWhite MatterYoung Adult

Identifiers

PMID31094489
PMCPMC6821510
OpenAlexW2982063848

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.