ArticleLab on a chip2019
3D printed microfluidic device for online detection of neurochemical changes with high temporal resolution in human brain microdialysate.
Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Noninvasive measurement of glucose and lactate in thermoregulatory sweat in neonates and adults.Science advances · 2026Article
- 3D Printing Assisted Wearable and Implantable Biosensors.Biosensors · 2025Review
- Recent Advances in Flexible Sensors for Neural Interfaces: Multimodal Sensing, Signal Integration, and Closed-Loop Feedback.Biosensors · 2025Review
- The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study.ACS chemical neuroscience · 2025Article
- Transdisciplinary Innovations in Athlete Health: 3D-Printable Wearable Sensors for Health Monitoring and Sports Psychology.Sensors (Basel, Switzerland) · 2025Review
- 3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications.Chemistry, an Asian journal · 2024Review
- Improving Sensitivity and Longevity of In Vivo Glutamate Sensors with Electrodeposited NanoPt.ACS applied materials & interfaces · 2024Article
- Sensor-integrated brain-on-a-chip platforms: Improving the predictive validity in neurodegenerative research.Bioengineering & translational medicine · 2024Review
- Computational Modeling as a Tool to Drive the Development of a Novel, Chemical Device for Monitoring the Injured Brain and Body.ACS chemical neuroscience · 2023Article
- Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of OACS chemical neuroscience · 2023Article
- Significance of an Electrochemical Sensor and Nanocomposites: Toward the Electrocatalytic Detection of Neurotransmitters and Their Importance within the Physiological System.ACS nanoscience Au · 2023Review
- 3D printing in biotechnology-An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics.Engineering in life sciences · 2022Review
- Recent Advances in 3D Printing of Biomedical Sensing Devices.Advanced functional materials · 2022Article
- A Low-Cost 3-in-1 3D Printer as a Tool for the Fabrication of Flow-Through Channels of Microfluidic Systems.Micromachines · 2021Article
- Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring.Molecules (Basel, Switzerland) · 2021Review
- Traumatic brain injury neuroelectrochemical monitoring: behind-the-ear micro-instrument and cloud application.Journal of neuroengineering and rehabilitation · 2020Article
- 3D-Printed Microfluidic Device with In-line Amperometric Detection that Also Enables Multi-Modal Detection.Analytical methods : advancing methods and applications · 2020Article
- Biofabrication for neural tissue engineering applications.Materials today. Bio · 2020Review
- Clinical translation of microfluidic sensor devices: focus on calibration and analytical robustness.Lab on a chip · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
This paper presents the design, optimisation and fabrication of a mechanically robust 3D printed microfluidic device for the high time resolution online analysis of biomarkers in a microdialysate stream at microlitre per minute flow rates. The device consists of a microfluidic channel with secure low volume connections that easily integrates electrochemical biosensors for biomarkers such as glutamate, glucose and lactate. The optimisation process of the microfluidic channel fabrication, including for different types of 3D printer, is explained and the resulting improvement in sensor response time is quantified. The time resolution of the device is characterised by recording short lactate concentration pulses. The device is employed to record simultaneous glutamate, glucose and lactate concentration changes simulating the physiological response to spreading depolarisation events in cerebrospinal fluid dialysate. As a proof-of-concept study, the device is then used in the intensive care unit for online monitoring of a brain injury patient, demonstrating its capabilities for clinical monitoring.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.